Guanethidine sulfateProduct ingredient for Guanethidine
- Name
- Guanethidine sulfate
- Drug Entry
- Guanethidine
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues. [PubChem]
- Accession Number
- DBSALT001861
- Structure
Structure for Guanethidine sulfate (DBSALT001861)
- Synonyms
- (2-(Hexahydro-1(2H)-azocinyl)ethyl)guanidine sulfate (2:1) / Azocine, 1-(2-guanidinoethyl)octahydro-, sulfate (2:1) / beta-1-Azacyclooctylethylguanidine sulfate / Guanethidine bisulfate / Guanethidine sulphate / Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, sulfate (2:1) / Guanidine, (2-(octahydro-1-azocinyl)ethyl)-, hemisulfate
- External IDs
- SU-5864
- UNII
- 8AQ60474G9
- CAS Number
- 60-02-6
- Weight
- Average: 494.7
Monoisotopic: 494.336273167 - Chemical Formula
- C20H46N8O4S
- InChI Key
- NBJGGHFXCGHTNJ-UHFFFAOYSA-N
- InChI
- InChI=1S/2C10H22N4.H2O4S/c2*11-10(12)13-6-9-14-7-4-2-1-3-5-8-14;1-5(2,3)4/h2*1-9H2,(H4,11,12,13);(H2,1,2,3,4)
- IUPAC Name
- bis(N-[2-(azocan-1-yl)ethyl]guanidine); sulfuric acid
- SMILES
- OS(O)(=O)=O.NC(=N)NCCN1CCCCCCC1.NC(=N)NCCN1CCCCCCC1
- External Links
- KEGG Drug
- D02237
- ChemSpider
- 58812
- ChEBI
- 51017
- ChEMBL
- CHEMBL2051958
- Predicted Properties
Property Value Source Water Solubility 1.02 mg/mL ALOGPS logP 0.78 ALOGPS logP 0.8 Chemaxon logS -2.3 ALOGPS pKa (Strongest Basic) 12.23 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 65.14 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 70 m3·mol-1 Chemaxon Polarizability 23.78 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon