Saprisartan potassiumProduct ingredient for Saprisartan
- Name
- Saprisartan potassium
- Drug Entry
- Saprisartan
Saprisartan is an AT1 receptor antagonist. It is based on medications of losartan's prototypical chemical structure. The mode of (functional) AT1 receptor antagonism has been characterized as insurmountable/noncompetitive for saprisartan. It is very likely that slow dissociation kinetics from the AT1 receptor underlie insurmountable antagonism 1.
- Accession Number
- DBSALT001863
- Structure
Structure for Saprisartan potassium (DBSALT001863)
- Synonyms
- 1-((3-bromo-2-(2-(((trifluoro-methyl)sulfonyl)amino)phenyl)-5-benzofuranyl)methyl)-4-cyclopropyl-2-ethyl-1h-imidazole-5-carboxamide potassium / 1-((3-bromo-2-(o-(1,1,1-(trifluoromethanesulfonamido)phenyl)-5-benzofuranyl)methyl)-4-cyclopropyl-2-ethylimidazole-5-carboxamide, monopotassium salt
- External IDs
- GR-138950C
- UNII
- T28707PG7T
- CAS Number
- 146613-90-3
- Weight
- Average: 649.52
Monoisotopic: 648.005605 - Chemical Formula
- C25H21BrF3KN4O4S
- InChI Key
- IASZJGRIPLTJMA-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H21BrF3N4O4S.K/c1-2-19-31-21(14-8-9-14)22(24(30)34)33(19)12-13-7-10-18-16(11-13)20(26)23(37-18)15-5-3-4-6-17(15)32-38(35,36)25(27,28)29;/h3-7,10-11,14H,2,8-9,12H2,1H3,(H2,30,34);/q-1;+1
- IUPAC Name
- potassium 1-({3-bromo-2-[2-(trifluoromethanesulfonylazanidyl)phenyl]-1-benzofuran-5-yl}methyl)-4-cyclopropyl-2-ethyl-1H-imidazole-5-carboximidic acid
- SMILES
- [K+].CCC1=NC(C2CC2)=C(N1CC1=CC2=C(OC(=C2Br)C2=CC=CC=C2[N-]S(=O)(=O)C(F)(F)F)C=C1)C(O)=N
- External Links
- ChemSpider
- 54891
- ChEMBL
- CHEMBL3989726
- Predicted Properties
Property Value Source Water Solubility 0.0235 mg/mL ALOGPS logP 5.94 ALOGPS logP 4.68 Chemaxon logS -4.4 ALOGPS pKa (Strongest Acidic) 2.27 Chemaxon pKa (Strongest Basic) 6.12 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 118.41 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 147.28 m3·mol-1 Chemaxon Polarizability 54.71 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon