Ulobetasol propionateProduct ingredient for Ulobetasol
- Name
- Ulobetasol propionate
- Drug Entry
- Ulobetasol
Ulobetasol is a highly potent corticosteroid.6 It is structurally related to clobetasol.6 Due to its high potency, it is mainly prescribed in the treatment of severe plaque psoriasis and corticosteroid responsive dermatoses.7,8,10
Ulobetasol was granted FDA approval on 17 December 1990.7
- Accession Number
- DBSALT001867
- Structure
Structure for Ulobetasol propionate (DBSALT001867)
- Synonyms
- Halobetasol propionate / Miracorten
- External IDs
- BMY-30056 / CGP-14,458 / CGP-14458
- UNII
- 91A0K1TY3Z
- CAS Number
- 66852-54-8
- Weight
- Average: 484.96
Monoisotopic: 484.1828081 - Chemical Formula
- C25H31ClF2O5
- InChI Key
- BDSYKGHYMJNPAB-LICBFIPMSA-N
- InChI
- InChI=1S/C25H31ClF2O5/c1-5-21(32)33-25(20(31)12-26)13(2)8-15-16-10-18(27)17-9-14(29)6-7-22(17,3)24(16,28)19(30)11-23(15,25)4/h6-7,9,13,15-16,18-19,30H,5,8,10-12H2,1-4H3/t13-,15-,16-,18-,19-,22-,23-,24-,25-/m0/s1
- IUPAC Name
- (1R,2S,8S,10S,11S,13S,14R,15S,17S)-14-(2-chloroacetyl)-1,8-difluoro-17-hydroxy-2,13,15-trimethyl-5-oxotetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-dien-14-yl propanoate
- SMILES
- [H][C@@]12C[C@H](C)[C@](OC(=O)CC)(C(=O)CCl)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C
- External Links
- ChemSpider
- 5293389
- ChEBI
- 135782
- ChEMBL
- CHEMBL1200908
- ZINC
- ZINC000003920028
- Wikipedia
- Ulobetasol_propionate
- Predicted Properties
Property Value Source Water Solubility 0.00757 mg/mL ALOGPS logP 3.81 ALOGPS logP 3.84 Chemaxon logS -4.8 ALOGPS pKa (Strongest Acidic) 13.55 Chemaxon pKa (Strongest Basic) -3.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 80.67 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 119.15 m3·mol-1 Chemaxon Polarizability 48.1 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon