Tridolgosir hydrochlorideProduct ingredient for Tridolgosir
- Name
- Tridolgosir hydrochloride
- Drug Entry
- Tridolgosir
An indolizidine alkaloid from the plant Swainsona canescens that is a potent alpha-mannosidase inhibitor. Swainsonine also exhibits antimetastatic, antiproliferative, and immunomodulatory activity.
- Accession Number
- DBSALT001877
- Structure
Structure for Tridolgosir hydrochloride (DBSALT001877)
- Synonyms
- Swainsonine HCl / Tridolgosir HCl
- External IDs
- GD-0039 / GD0039
- UNII
- 78KR51ES9B
- CAS Number
- 214462-68-7
- Weight
- Average: 209.67
Monoisotopic: 209.0818711 - Chemical Formula
- C8H16ClNO3
- InChI Key
- LIRVFCZWYJVKCV-XNJRRJNCSA-N
- InChI
- InChI=1S/C8H15NO3.ClH/c10-5-2-1-3-9-4-6(11)8(12)7(5)9;/h5-8,10-12H,1-4H2;1H/t5-,6-,7-,8-;/m1./s1
- IUPAC Name
- (1S,2R,8R,8aR)-octahydroindolizine-1,2,8-triol hydrochloride
- SMILES
- Cl.[H][C@@]12[C@H](O)[C@H](O)CN1CCC[C@H]2O
- External Links
- ChemSpider
- 8012924
- ChEMBL
- CHEMBL2107226
- Predicted Properties
Property Value Source Water Solubility 1320.0 mg/mL ALOGPS logP -1.5 ALOGPS logP -1.4 Chemaxon logS 0.88 ALOGPS pKa (Strongest Acidic) 13.28 Chemaxon pKa (Strongest Basic) 9.47 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 63.93 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 43.12 m3·mol-1 Chemaxon Polarizability 18.06 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon