Oxilofrine hydrochlorideProduct ingredient for Oxilofrine
- Name
- Oxilofrine hydrochloride
- Drug Entry
- Oxilofrine
Oxilofrine is used in combination with Normethadone as an antitussive. It is currently marketed in Canada by Valeant under the tradename Cophylac.
- Accession Number
- DBSALT001920
- Structure
Structure for Oxilofrine hydrochloride (DBSALT001920)
- Synonyms
- 4-hydroxyephedrine hydrochloride / Oxilofrine HCl / p-hydroxyephedrine hydrochloride / Suprifen hydrochloride
- UNII
- 3O9694M5EO
- CAS Number
- 942-51-8
- Weight
- Average: 217.69
Monoisotopic: 217.0869565 - Chemical Formula
- C10H16ClNO2
- InChI Key
- ICBZSKCTKKUQSY-YUWZRIFDSA-N
- InChI
- InChI=1S/C10H15NO2.ClH/c1-7(11-2)10(13)8-3-5-9(12)6-4-8;/h3-7,10-13H,1-2H3;1H/t7-,10-;/m0./s1
- IUPAC Name
- 4-[(1R,2S)-1-hydroxy-2-(methylamino)propyl]phenol hydrochloride
- SMILES
- Cl.[H][C@@](C)(NC)[C@]([H])(O)C1=CC=C(O)C=C1
- External Links
- Not Available
- Predicted Properties
Property Value Source Water Solubility 12.2 mg/mL ALOGPS logP -0.13 ALOGPS logP 0.28 Chemaxon logS -1.2 ALOGPS pKa (Strongest Acidic) 9.19 Chemaxon pKa (Strongest Basic) 9.8 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 52.49 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 51.67 m3·mol-1 Chemaxon Polarizability 19.98 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon