Doxazosin mesylateProduct ingredient for Doxazosin
- Name
- Doxazosin mesylate
- Drug Entry
- Doxazosin
Doxazosin is an alpha-1 antagonist used for the treatment of benign prostatic hypertrophy (BPH) symptoms and hypertension. Other members of this drug class include Prazosin, Terazosin, Tamsulosin, and Alfuzosin.8 Because of its long-lasting effects, doxazosin can be administered once a day.5 It is marketed by Pfizer and was initially approved by the FDA in 1990.20
- Accession Number
- DBSALT001948
- Structure
- Synonyms
- Doxazosin (as mesilate) / Doxazosin mesilate / Doxazosin methanesulfonate / Methanesulfonate (1:1)
- External IDs
- UK-33,274-27
- UNII
- 86P6PQK0MU
- CAS Number
- 77883-43-3
- Weight
- Average: 547.58
Monoisotopic: 547.173684088 - Chemical Formula
- C24H29N5O8S
- InChI Key
- VJECBOKJABCYMF-UHFFFAOYSA-N
- InChI
- InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4)
- IUPAC Name
- 2-[4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl]-6,7-dimethoxy-3,4-dihydroquinazolin-4-imine; methanesulfonic acid
- SMILES
- CS(O)(=O)=O.COC1=C(OC)C=C2C(=N)NC(=NC2=C1)N1CCN(CC1)C(=O)C1COC2=CC=CC=C2O1
- External Links
- KEGG Drug
- D00608
- ChemSpider
- 56686
- ChEBI
- 4709
- ChEMBL
- CHEMBL1200561
- Wikipedia
- Doxazosin
- Predicted Properties
Property Value Source Water Solubility 0.112 mg/mL ALOGPS logP 1.49 ALOGPS logP 1.32 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 12.39 Chemaxon pKa (Strongest Basic) 5.45 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 108.71 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 132.18 m3·mol-1 Chemaxon Polarizability 46.68 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon