Frovatriptan succinate anhydrousProduct ingredient for Frovatriptan
- Name
- Frovatriptan succinate anhydrous
- Drug Entry
- Frovatriptan
Frovatriptan is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head.
- Accession Number
- DBSALT001957
- Structure
Structure for Frovatriptan succinate anhydrous (DBSALT001957)
- Synonyms
- Not Available
- UNII
- 36K05YF32G
- CAS Number
- 158930-09-7
- Weight
- Average: 361.398
Monoisotopic: 361.163770853 - Chemical Formula
- C18H23N3O5
- InChI Key
- WHTHWNUUXINXHN-SBSPUUFOSA-N
- InChI
- InChI=1S/C14H17N3O.C4H6O4/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8)/t9-;/m1./s1
- IUPAC Name
- (3R)-3-(methylamino)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide; butanedioic acid
- SMILES
- OC(=O)CCC(O)=O.CN[C@@H]1CCC2=C(C1)C1=C(N2)C=CC(=C1)C(N)=O
- External Links
- ChemSpider
- 134800
- ChEMBL
- CHEMBL1200371
- Wikipedia
- Frovatriptan
- Predicted Properties
Property Value Source Water Solubility 0.123 mg/mL ALOGPS logP 1.2 ALOGPS logP 1.08 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 14.54 Chemaxon pKa (Strongest Basic) 10.42 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 70.91 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 71.84 m3·mol-1 Chemaxon Polarizability 27.64 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon