Tolperisone hydrochlorideProduct ingredient for Tolperisone
- Name
- Tolperisone hydrochloride
- Drug Entry
- Tolperisone
Tolperisone is an oral, centrally acting muscle relaxant. Its precise mechanism is not completely understood, though it blocks sodium and calcium channels. It possesses a high affinity for nervous system tissue, reaching highest concentrations in brain stem, spinal cord and peripheral nerves. Based on existing clinical data, Tolperisone is not sedating and does not interact with alcohol.
- Accession Number
- DBSALT002004
- Structure
Structure for Tolperisone hydrochloride (DBSALT002004)
- Synonyms
- Not Available
- UNII
- 8Z075K2TIG
- CAS Number
- 3644-61-9
- Weight
- Average: 281.82
Monoisotopic: 281.1546421 - Chemical Formula
- C16H24ClNO
- InChI Key
- ZBUVYROEHQQAKL-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
- IUPAC Name
- 2-methyl-1-(4-methylphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride
- SMILES
- Cl.CC(CN1CCCCC1)C(=O)C1=CC=C(C)C=C1
- External Links
- ChemSpider
- 83919
- ChEBI
- 32244
- ChEMBL
- CHEMBL1395150
- Predicted Properties
Property Value Source Water Solubility 0.167 mg/mL ALOGPS logP 3.75 ALOGPS logP 3.57 Chemaxon logS -3.2 ALOGPS pKa (Strongest Acidic) 16.51 Chemaxon pKa (Strongest Basic) 8.78 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 20.31 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 76.35 m3·mol-1 Chemaxon Polarizability 29.14 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon