Avatrombopag maleateProduct ingredient for Avatrombopag
- Name
- Avatrombopag maleate
- Drug Entry
- Avatrombopag
Avatrombopag (Doptelet), is an orally administered, small molecule thrombopoietin receptor (c-Mpl) agonist that increases platelet number without increasing platelet activation,3,10 thereby decreasing the need for blood transfusions.10 Patients with thrombocytopenia and chronic liver disease often require platelet transfusions before surgical procedures to decrease the risk of bleeding.1 Thrombocytopenia is a common complication in patients suffering from chronic liver disease, occurring as a result of liver disease or a consequence of interferon-based antiviral therapy.18
Avatrombopag was first approved by the FDA in May 2018 for use in adults with chronic liver disease who are scheduled to undergo a procedure.14 It is administered orally as the salt form avatrombopag maleate.11 Doptelet (Avatrombopag) is the first orally administered treatment option for patients with chronic liver disease, allowing a large population of patients to avoid a platelet transfusion before a procedure by increasing platelet counts to the optimal level ≥50,000 per microliter.15
- Accession Number
- DBSALT002118
- Structure
Structure for Avatrombopag maleate (DBSALT002118)
- Synonyms
- Not Available
- UNII
- GDW7M2P1IS
- CAS Number
- 677007-74-8
- Weight
- Average: 765.72
Monoisotopic: 764.1620453 - Chemical Formula
- C33H38Cl2N6O7S2
- InChI Key
- MISPBGHDNZYFNM-BTJKTKAUSA-N
- InChI
- InChI=1S/C29H34Cl2N6O3S2.C4H4O4/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;5-3(6)1-2-4(7)8/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1-2H,(H,5,6)(H,7,8)/b;2-1-
- IUPAC Name
- (2Z)-but-2-enedioic acid; 1-(3-chloro-5-{[4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)-1,3-thiazol-2-yl]carbamoyl}pyridin-2-yl)piperidine-4-carboxylic acid
- SMILES
- OC(=O)\C=C/C(O)=O.OC(=O)C1CCN(CC1)C1=C(Cl)C=C(C=N1)C(=O)NC1=NC(C2=CC(Cl)=CS2)=C(S1)N1CCN(CC1)C1CCCCC1
- External Links
- ChemSpider
- 8094226
- ChEMBL
- CHEMBL2105758
- PharmGKB
- PA166179849
- Predicted Properties
Property Value Source Water Solubility 0.00465 mg/mL ALOGPS logP 5.97 ALOGPS logP 4.17 Chemaxon logS -5.2 ALOGPS pKa (Strongest Acidic) 3.5 Chemaxon pKa (Strongest Basic) 8.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 101.9 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 169.16 m3·mol-1 Chemaxon Polarizability 69.92 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon