Hydrocodone hydrochlorideProduct ingredient for Hydrocodone
- Name
- Hydrocodone hydrochloride
- Drug Entry
- Hydrocodone
Hydrocodone is a synthetic opioid derivative of codeine.14 It is commonly used in combination with acetaminophen to control moderate to severe pain. Historically, hydrocodone has been used as a cough suppressant although this has largely been replaced by dextromethorphan in current cough and cold formulations. Hydrocodone's more potent metabolite, hydromorphone has also found wide use as an analgesic and is frequently used in cases of severe pain. The FDA first approved Hydrocodone for use as part of the cough suppressant syrup Hycodan in March of 1943.17
- Accession Number
- DBSALT002210
- Structure
- Synonyms
- Hydrocodone HCL
- UNII
- QKZ0920OV3
- CAS Number
- 25968-91-6
- Weight
- Average: 335.83
Monoisotopic: 335.1288213 - Chemical Formula
- C18H22ClNO3
- InChI Key
- GCJAEXSZUXBMFS-RNWHKREASA-N
- InChI
- InChI=1S/C18H21NO3.ClH/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;/h3,6,11-12,17H,4-5,7-9H2,1-2H3;1H/t11-,12+,17-,18-;/m0./s1
- IUPAC Name
- (1S,5R,13R,17R)-10-methoxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0^{1,13}.0^{5,17}.0^{7,18}]octadeca-7(18),8,10-trien-14-one hydrochloride
- SMILES
- Cl.COC1=C2O[C@H]3C(=O)CC[C@H]4[C@H]5CC(C=C1)=C2[C@@]34CCN5C
- External Links
- ChemSpider
- 20014295
- Predicted Properties
Property Value Source Water Solubility 0.797 mg/mL ALOGPS logP 2.13 ALOGPS logP 1.96 Chemaxon logS -2.6 ALOGPS pKa (Strongest Acidic) 18 Chemaxon pKa (Strongest Basic) 8.61 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 38.77 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 82.74 m3·mol-1 Chemaxon Polarizability 32.02 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon