Diazepam hydrochlorideProduct ingredient for Diazepam
- Name
- Diazepam hydrochloride
- Drug Entry
- Diazepam
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of gamma-aminobutyric acid activity. It is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. (From Martindale, The Extra Pharmacopoeia, 30th ed, p589)
Given diazepam's storied history as a commonly used and effective medication for a variety of indications, contemporary advancements in the formulation and administration of the agent include the development and US FDA approval of an auto-injectable formulation for the rapid treatment of uncontrolled seizures in 2015-2016 7. Combining diazepam, a proven effective therapy for acute repetitive seizures, with an auto-injector designed for subcutaneous administration that is quickly and easily administered offers the potential for complete, consistent drug absorption and rapid onset of effect 7. This current development is subsequently an important addition to the rescue therapy tool chest for patients with epilepsy 7.
- Accession Number
- DBSALT002258
- Structure
Structure for Diazepam hydrochloride (DBSALT002258)
- Synonyms
- Not Available
- UNII
- 6JD21U639H
- CAS Number
- 52468-36-7
- Weight
- Average: 321.2
Monoisotopic: 320.0483185 - Chemical Formula
- C16H14Cl2N2O
- InChI Key
- BPYZIOINRAWEQL-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H13ClN2O.ClH/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11;/h2-9H,10H2,1H3;1H
- IUPAC Name
- 7-chloro-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one hydrochloride
- SMILES
- Cl.CN1C2=CC=C(Cl)C=C2C(=NCC1=O)C1=CC=CC=C1
- External Links
- ChemSpider
- 4955073
- ChEMBL
- CHEMBL543191
- Predicted Properties
Property Value Source Water Solubility 0.0122 mg/mL ALOGPS logP 2.63 ALOGPS logP 3.08 Chemaxon logS -4.4 ALOGPS pKa (Strongest Basic) 2.92 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 32.67 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 79.81 m3·mol-1 Chemaxon Polarizability 29.39 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon