Cinnarizine hydrochlorideProduct ingredient for Cinnarizine
- Name
- Cinnarizine hydrochloride
- Drug Entry
- Cinnarizine
First synthesized by Janssen Pharmaceuticals in 1955, cinnarizine is an anti-histaminic drug mainly used for the control of vestibular disorders and motion sickness. Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus. Cinnarizine could be also viewed as a nootropic drug because of its vasorelaxating abilities (due to calcium channel blockage), which happen mostly in brain. Combination use of cinnarizine with other nootropics, such as piracetam resulted in enhanced effect of boosting brain oxygen supply.
- Accession Number
- DBSALT002261
- Structure
Structure for Cinnarizine hydrochloride (DBSALT002261)
- Synonyms
- Not Available
- UNII
- 5AKM4OA6VO
- CAS Number
- 25332-14-3
- Weight
- Average: 404.98
Monoisotopic: 404.2019266 - Chemical Formula
- C26H29ClN2
- InChI Key
- LYXJDKBTSDYXQV-RSGUCCNWSA-N
- InChI
- InChI=1S/C26H28N2.ClH/c1-4-11-23(12-5-1)13-10-18-27-19-21-28(22-20-27)26(24-14-6-2-7-15-24)25-16-8-3-9-17-25;/h1-17,26H,18-22H2;1H/b13-10+;
- IUPAC Name
- 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine hydrochloride
- SMILES
- Cl.C(\C=C\C1=CC=CC=C1)N1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- ChemSpider
- 15498209
- Predicted Properties
Property Value Source Water Solubility 0.00172 mg/mL ALOGPS logP 5.19 ALOGPS logP 5.88 Chemaxon logS -5.3 ALOGPS pKa (Strongest Basic) 8.1 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 6.48 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 119.86 m3·mol-1 Chemaxon Polarizability 43.95 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon