Temazepam sulfateProduct ingredient for Temazepam

Name
Temazepam sulfate
Drug Entry
Temazepam

Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action 6,7,13,14.

Although the chemical synthesis of temazepam was established by 1965 9, mainstream contemporary use of the medication did not occur until it's legitimate use as treatment for insomnia was accepted and approved later on. In particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to obtain the necessary rest required for medical recovery or scheduled maneuvers and operations 10. Regardless, temazepam has become one of the most frequently prescribed medications internationally and sees millions of prescriptions every year. Unfortunately, however, given its frequent use and the inherent nature of its pharmacological effects, temazepam - like many other benzodiazepines - possesses a high potential for misuse and is genuinely capable of developing drug tolerance, physical dependence, and addiction in users.

Accession Number
DBSALT002271
Structure
Synonyms
Not Available
UNII
I1HX8463I0
CAS Number
31677-86-8
Weight
Average: 398.81
Monoisotopic: 398.0339351
Chemical Formula
C16H15ClN2O6S
InChI Key
XNBFXTXDZMWXMN-UHFFFAOYSA-N
InChI
InChI=1S/C16H13ClN2O2.H2O4S/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10;1-5(2,3)4/h2-9,15,20H,1H3;(H2,1,2,3,4)
IUPAC Name
7-chloro-3-hydroxy-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; sulfuric acid
SMILES
OS(O)(=O)=O.CN1C2=CC=C(Cl)C=C2C(=NC(O)C1=O)C1=CC=CC=C1
ChemSpider
58827958
Predicted Properties
PropertyValueSource
Water Solubility0.0534 mg/mLALOGPS
logP2.16ALOGPS
logP2.79Chemaxon
logS-3.8ALOGPS
pKa (Strongest Acidic)10.68Chemaxon
pKa (Strongest Basic)-1.4Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area52.9 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity81.01 m3·mol-1Chemaxon
Polarizability30.32 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon