Temazepam sulfateProduct ingredient for Temazepam
- Name
- Temazepam sulfate
- Drug Entry
- Temazepam
Temazepam, like many other similar and related benzodiazepines, acts as a gamma-aminobutyric acid (GABA) modulator and is capable of eliciting a variety of actions including sedation, hypnosis, skeletal muscle relaxation, anticonvulsant activity, and anxiolytic action 6,7,13,14.
Although the chemical synthesis of temazepam was established by 1965 9, mainstream contemporary use of the medication did not occur until it's legitimate use as treatment for insomnia was accepted and approved later on. In particular, before temazepam saw regular prescription use in civilians it was - and still is - employed by the US military as a sedative-hypnotic medication to be taken by soldiers, pilots, etc. to obtain the necessary rest required for medical recovery or scheduled maneuvers and operations 10. Regardless, temazepam has become one of the most frequently prescribed medications internationally and sees millions of prescriptions every year. Unfortunately, however, given its frequent use and the inherent nature of its pharmacological effects, temazepam - like many other benzodiazepines - possesses a high potential for misuse and is genuinely capable of developing drug tolerance, physical dependence, and addiction in users.
- Accession Number
- DBSALT002271
- Structure
- Synonyms
- Not Available
- UNII
- I1HX8463I0
- CAS Number
- 31677-86-8
- Weight
- Average: 398.81
Monoisotopic: 398.0339351 - Chemical Formula
- C16H15ClN2O6S
- InChI Key
- XNBFXTXDZMWXMN-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H13ClN2O2.H2O4S/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10;1-5(2,3)4/h2-9,15,20H,1H3;(H2,1,2,3,4)
- IUPAC Name
- 7-chloro-3-hydroxy-1-methyl-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one; sulfuric acid
- SMILES
- OS(O)(=O)=O.CN1C2=CC=C(Cl)C=C2C(=NC(O)C1=O)C1=CC=CC=C1
- External Links
- ChemSpider
- 58827958
- Predicted Properties
Property Value Source Water Solubility 0.0534 mg/mL ALOGPS logP 2.16 ALOGPS logP 2.79 Chemaxon logS -3.8 ALOGPS pKa (Strongest Acidic) 10.68 Chemaxon pKa (Strongest Basic) -1.4 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 52.9 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 81.01 m3·mol-1 Chemaxon Polarizability 30.32 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon