Mirtazapine hydrochlorideProduct ingredient for Mirtazapine
- Name
- Mirtazapine hydrochloride
- Drug Entry
- Mirtazapine
Mirtazapine is a tetracyclic piperazino-azepine antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994.13 This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major depressive disorder.29,31 The effects of this drug may be observed as early as 1 week after beginning therapy.21,32
In addition to its beneficial effects in depression, mirtazapine has been reported to be efficacious in the off-label management of various other conditions. It may improve the symptoms of neurological disorders, reverse weight loss caused by medical conditions, improve sleep, and prevent nausea and vomiting after surgery.9
- Accession Number
- DBSALT002298
- Structure
Structure for Mirtazapine hydrochloride (DBSALT002298)
- Synonyms
- Not Available
- UNII
- 42CIX4573G
- CAS Number
- 207516-99-2
- Weight
- Average: 301.82
Monoisotopic: 301.1345754 - Chemical Formula
- C17H20ClN3
- InChI Key
- SISMRXGXKXMBKT-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H19N3.ClH/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20;/h2-8,16H,9-12H2,1H3;1H
- IUPAC Name
- 5-methyl-2,5,19-triazatetracyclo[13.4.0.0^{2,7}.0^{8,13}]nonadeca-1(15),8,10,12,16,18-hexaene hydrochloride
- SMILES
- Cl.CN1CCN2C(C1)C1=CC=CC=C1CC1=C2N=CC=C1
- External Links
- ChemSpider
- 9869874
- Predicted Properties
Property Value Source Water Solubility 1.1 mg/mL ALOGPS logP 2.9 ALOGPS logP 3.21 Chemaxon logS -2.4 ALOGPS pKa (Strongest Basic) 6.67 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 19.37 Å2 Chemaxon Rotatable Bond Count 0 Chemaxon Refractivity 82.66 m3·mol-1 Chemaxon Polarizability 30.29 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon