Fosamprenavir sodiumProduct ingredient for Fosamprenavir
- Name
- Fosamprenavir sodium
- Drug Entry
- Fosamprenavir
Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
- Accession Number
- DBSALT002341
- Structure
Structure for Fosamprenavir sodium (DBSALT002341)
- Synonyms
- Not Available
- UNII
- XSG28FSA0W
- CAS Number
- 226700-80-7
- Weight
- Average: 629.57
Monoisotopic: 629.15487642 - Chemical Formula
- C25H34N3Na2O9PS
- InChI Key
- FZMGUXZZROZJIT-KMIZVRHLSA-L
- InChI
- InChI=1S/C25H36N3O9PS.2Na/c1-18(2)15-28(39(33,34)22-10-8-20(26)9-11-22)16-24(37-38(30,31)32)23(14-19-6-4-3-5-7-19)27-25(29)36-21-12-13-35-17-21;;/h3-11,18,21,23-24H,12-17,26H2,1-2H3,(H,27,29)(H2,30,31,32);;/q;2*+1/p-2/t21-,23-,24+;;/m0../s1
- IUPAC Name
- disodium 4-amino-N-(2-methylpropyl)-N-[(2R,3S)-3-({[(3S)-oxolan-3-yloxy]carbonyl}amino)-4-phenyl-2-(phosphonooxy)butyl]benzene-1-sulfonamide
- SMILES
- [Na+].[Na+].CC(C)CN(C[C@@H](OP([O-])([O-])=O)[C@H](CC1=CC=CC=C1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)C1=CC=C(N)C=C1
- External Links
- ChemSpider
- 116246
- ChEMBL
- CHEMBL2106751
- Predicted Properties
Property Value Source Water Solubility 0.466 mg/mL ALOGPS logP 1.99 ALOGPS logP 1.92 Chemaxon logS -3.1 ALOGPS pKa (Strongest Acidic) 1.22 Chemaxon pKa (Strongest Basic) 2.45 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 8 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 183.38 Å2 Chemaxon Rotatable Bond Count 13 Chemaxon Refractivity 142.71 m3·mol-1 Chemaxon Polarizability 57.08 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon