Etifoxine hydrochlorideProduct ingredient for Etifoxine
- Name
- Etifoxine hydrochloride
- Drug Entry
- Etifoxine
Etifoxine is an anxiolytic and anticonvulsant drug developed by Hoechst in the 1960s. It is used in anxiety disorders and to promote peripheral nerve healing. It does not bind to the benzodiazepine receptor though the effects are similar to that of benzodiazepines. It is more effective than lorazepam as an anxiolytic, and has fewer side effects. Etifoxine has been associated with acute liver injury.
- Accession Number
- DBSALT002449
- Structure
Structure for Etifoxine hydrochloride (DBSALT002449)
- Synonyms
- Etifoxine HCl
- UNII
- NBL8010WH5
- CAS Number
- 56776-32-0
- Weight
- Average: 337.244
Monoisotopic: 336.079618622 - Chemical Formula
- C17H18Cl2N2O
- InChI Key
- SCBJXEBIMVRTJE-UHFFFAOYSA-N
- InChI
- InChI=1S/C17H17ClN2O.ClH/c1-3-19-16-20-15-10-9-13(18)11-14(15)17(2,21-16)12-7-5-4-6-8-12;/h4-11H,3H2,1-2H3,(H,19,20);1H
- IUPAC Name
- 6-chloro-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride
- SMILES
- Cl.CCNC1=NC2=CC=C(Cl)C=C2C(C)(O1)C1=CC=CC=C1
- External Links
- ChemSpider
- 149958
- Predicted Properties
Property Value Source Water Solubility 0.00216 mg/mL ALOGPS logP 4.52 ALOGPS logP 4.59 Chemaxon logS -5.1 ALOGPS pKa (Strongest Basic) 5.18 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 33.62 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 87.23 m3·mol-1 Chemaxon Polarizability 32.25 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon