Sodium iodide I-123Product ingredient for Iodide I-123

Name
Sodium iodide I-123
Drug Entry
Iodide I-123

Iodide I-123 (as sodium Iodide I-123) is a radioactive isotope of iodine used in nuclear medicine for the diagnostic study of thyroid disease. Following oral administration, I-123 is absorbed through the gastrointestinal tract and is taken up by the thyroid gland. After incorporation, a gamma camera is used to detect the decay by electron capture to tellurium-123.

Iodine is commonly used in thyroid function diagnostic tests as this gland normally absorbs iodine through the diet for formation of the thyroid hormones triiodothyronine (T3) and its prohormone, thyroxine (T4). Radioactive I-123 in particular is effective for this use as its half-life of approximately 13.13 h (hours) is ideal for the 24-h (hour) iodine uptake test and it has a reduced radiation burden as compared to I-131.

Accession Number
DBSALT002459
Structure
Synonyms
Sodio ioduro (123I) / Sodium iodide (123 I) / Sodium iodide (123I) / Sodium iodide I 123 / Sodium iodide, I-123 / Sodium iodide,I-123
UNII
29UKX3A616
CAS Number
41927-88-2
Weight
Average: 145.8954
Monoisotopic: 145.89536722
Chemical Formula
INa
InChI Key
FVAUCKIRQBBSSJ-VVUPZWBASA-M
InChI
InChI=1S/HI.Na/h1H;/q;+1/p-1/i1-4;
IUPAC Name
sodium (123I)iodide
SMILES
[Na+].[123I-]
ChemSpider
9172363
ChEMBL
CHEMBL1201083
Predicted Properties
PropertyValueSource
logP1.02Chemaxon
pKa (Strongest Acidic)-9Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count0Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area0 Å2Chemaxon
Rotatable Bond Count0Chemaxon
Refractivity13.95 m3·mol-1Chemaxon
Polarizability5.07 Å3Chemaxon
Number of Rings0Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon