Methylprednisolone aceponate

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Summary

Methylprednisolone aceponate is a corticosteroid indicated in the treatment of corticosteroid-responsive dermatoses.

Generic Name
Methylprednisolone aceponate
DrugBank Accession Number
DB14643
Background

Not Available

Type
Small Molecule
Groups
Approved, Vet approved
Structure
Weight
Average: 472.578
Monoisotopic: 472.246103499
Chemical Formula
C27H36O7
Synonyms
  • Aceponato de metilprednisolona
  • Methylprednisolone aceponate
  • Methylprednisoloni aceponas
External IDs
  • BRN 5663614
  • SH-440
  • ZK91588

Pharmacology

Indication

Not Available

Reduce drug development failure rates
Build, train, & validate machine-learning models
with evidence-based and structured datasets.
See how
Build, train, & validate predictive machine-learning models with structured datasets.
See how
Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Symptomatic treatment ofAllergic contact eczema•••••••••••••••••
Symptomatic treatment ofAtopic dermatitis (ad)•••••••••••••••••• ••••••••• ••••••••
Symptomatic treatment ofDermatitis, eczematous•••••••••••••••••• ••••••••• ••••••••
Treatment ofDermatitis, eczematous••••••••••••
Symptomatic treatment ofEczema, contact•••••••••••••••••• ••••••••• ••••••••
Contraindications & Blackbox Warnings
Prevent Adverse Drug Events Today
Tap into our Clinical API for life-saving information on contraindications & blackbox warnings, population restrictions, harmful risks, & more.
Learn more
Avoid life-threatening adverse drug events with our Clinical API
Learn more
Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
Improve decision support & research outcomes
With structured adverse effects data, including: blackbox warnings, adverse reactions, warning & precautions, & incidence rates. View sample adverse effects data in our new Data Library!
See the data
Improve decision support & research outcomes with our structured adverse effects data.
See a data sample
Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
DrugInteraction
AcarboseThe risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Acarbose.
AceclofenacThe risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Aceclofenac.
AcemetacinThe risk or severity of gastrointestinal irritation can be increased when Methylprednisolone aceponate is combined with Acemetacin.
AcenocoumarolMethylprednisolone aceponate may increase the anticoagulant activities of Acenocoumarol.
AcetohexamideThe risk or severity of hyperglycemia can be increased when Methylprednisolone aceponate is combined with Acetohexamide.
Food Interactions
Not Available

Products

Drug product information from 10+ global regions
Our datasets provide approved product information including:
dosage, form, labeller, route of administration, and marketing period.
Access now
Access drug product information from over 10 global regions.
Access now
International/Other Brands
Advantan

Categories

ATC Codes
D07AC14 — Methylprednisolone aceponate
Drug Categories
Chemical TaxonomyProvided by Classyfire
Description
This compound belongs to the class of organic compounds known as gluco/mineralocorticoids, progestogins and derivatives. These are steroids with a structure based on a hydroxylated prostane moiety.
Kingdom
Organic compounds
Super Class
Lipids and lipid-like molecules
Class
Steroids and steroid derivatives
Sub Class
Pregnane steroids
Direct Parent
Gluco/mineralocorticoids, progestogins and derivatives
Alternative Parents
Steroid esters / 20-oxosteroids / 3-oxo delta-1,4-steroids / 11-beta-hydroxysteroids / Delta-1,4-steroids / Alpha-acyloxy ketones / Dicarboxylic acids and derivatives / Secondary alcohols / Cyclic ketones / Cyclic alcohols and derivatives
show 3 more
Substituents
11-beta-hydroxysteroid / 11-hydroxysteroid / 20-oxosteroid / 3-oxo-delta-1,4-steroid / 3-oxosteroid / Alcohol / Aliphatic homopolycyclic compound / Alpha-acyloxy ketone / Carbonyl group / Carboxylic acid derivative
show 15 more
Molecular Framework
Aliphatic homopolycyclic compounds
External Descriptors
Not Available
Affected organisms
Not Available

Chemical Identifiers

UNII
ET54W9J4U2
CAS number
86401-95-8
InChI Key
DALKLAYLIPSCQL-YPYQNWSCSA-N
InChI
InChI=1S/C27H36O7/c1-6-23(32)34-27(22(31)14-33-16(3)28)10-8-19-18-11-15(2)20-12-17(29)7-9-25(20,4)24(18)21(30)13-26(19,27)5/h7,9,12,15,18-19,21,24,30H,6,8,10-11,13-14H2,1-5H3/t15-,18-,19-,21-,24+,25-,26-,27-/m0/s1
IUPAC Name
(1R,3aS,3bS,5S,9aR,9bS,10S,11aS)-1-[2-(acetyloxy)acetyl]-10-hydroxy-5,9a,11a-trimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl propanoate
SMILES
[H][C@@]12CC[C@](OC(=O)CC)(C(=O)COC(C)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C

References

General References
  1. AIFA Package Leaflet: ADVANTAN (Methylprednisolone aceponate) for cutaneous use [Link]
ChemSpider
56717
ChEBI
135762
ChEMBL
CHEMBL1697782
ZINC
ZINC000004213828
Wikipedia
Methylprednisolone_aceponate

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
4CompletedPreventionAtopic Dermatitis1
4CompletedTreatmentAtopic Dermatitis1
1CompletedBasic ScienceNormal Physiology1
1CompletedSupportive CareEczema; Contact, Allergic1
Not AvailableCompletedTreatmentPsoriasis Vulgaris (Plaque Psoriasis)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
CreamCutaneous1 mg/g
CreamCutaneous1.000 mg
SolutionTopical1 mg/ml
EmulsionTopical0.1 g
OintmentTopical
CreamTopical0.1 %
OintmentTopical0.1 %
OintmentTopical0.1 percent
CreamTopical
CreamTopical30 g
SolutionOral0.1 %
EmulsionTopical0.1 %
SolutionTopical0.1 %
LotionTopical0.1 %
LotionTopical100 gr
LotionTopical50 gr
LotionTopical100 mg
LotionTopical10000000 mg
EmulsionTopical
SolutionOral1 MG/ML
EmulsionTopical1 MG/G
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.00637 mg/mLALOGPS
logP2.92ALOGPS
logP3.14Chemaxon
logS-4.9ALOGPS
pKa (Strongest Acidic)14.8Chemaxon
pKa (Strongest Basic)-2.9Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area106.97 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity125.97 m3·mol-1Chemaxon
Polarizability50.86 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-0abj-0005900000-6949032568b643e59f69
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-0abi-9006500000-bf9b149ea1f1cc07e254
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-0adi-9006000000-5771696f58ddd9e5c60c
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0a4i-0214900000-f80e0b0f5c2ffbeaff9a
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-00dl-9004000000-2e1c43fdf0a2e99b8176
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-0002-0941200000-7b73c66cbf5faa66a407
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-226.5826853
predicted
DarkChem Lite v0.1.0
[M-H]-205.19638
predicted
DeepCCS 1.0 (2019)
[M+H]+226.9043853
predicted
DarkChem Lite v0.1.0
[M+H]+207.02129
predicted
DeepCCS 1.0 (2019)
[M+Na]+227.1197853
predicted
DarkChem Lite v0.1.0
[M+Na]+213.26285
predicted
DeepCCS 1.0 (2019)

Drug created at September 01, 2018 21:20 / Updated at May 14, 2021 01:07