Clopidogrel hydrochlorideProduct ingredient for Clopidogrel
- Name
- Clopidogrel hydrochloride
- Drug Entry
- Clopidogrel
Clopidogrel is a prodrug of a platelet inhibitor used to reduce the risk of myocardial infarction and stroke.3,9 Clopidogrel is indicated to reduce the risk of myocardial infarction for patients with non-ST elevated acute coronary syndrome (ACS), patients with ST-elevated myocardial infarction, and in recent MI, stroke, or established peripheral arterial disease,9
It has been shown to be superior to aspirin in reducing cardiovascular outcomes in patients with cardiovascular disease and provides additional benefit to patients with acute coronary syndromes already taking aspirin.8
Clopidogrel was granted FDA approval on 17 November 1997.9
- Accession Number
- DBSALT002594
- Structure
Structure for Clopidogrel hydrochloride (DBSALT002594)
- Synonyms
- Not Available
- UNII
- 426O7XWS6Y
- CAS Number
- 120202-65-5
- Weight
- Average: 358.28
Monoisotopic: 357.0357054 - Chemical Formula
- C16H17Cl2NO2S
- InChI Key
- XIHVAFJSGWDBGA-RSAXXLAASA-N
- InChI
- InChI=1S/C16H16ClNO2S.ClH/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14;/h2-5,7,9,15H,6,8,10H2,1H3;1H/t15-;/m0./s1
- IUPAC Name
- methyl (2S)-2-(2-chlorophenyl)-2-{4H,5H,6H,7H-thieno[3,2-c]pyridin-5-yl}acetate hydrochloride
- SMILES
- Cl.COC(=O)[C@@H](N1CCC2=C(C1)C=CS2)C1=CC=CC=C1Cl
- External Links
- ChemSpider
- 7974626
- Predicted Properties
Property Value Source Water Solubility 0.0118 mg/mL ALOGPS logP 3.84 ALOGPS logP 4.03 Chemaxon logS -4.4 ALOGPS pKa (Strongest Basic) 4.77 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 29.54 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 84.93 m3·mol-1 Chemaxon Polarizability 33.19 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon