Prucalopride succinateProduct ingredient for Prucalopride
- Name
- Prucalopride succinate
- Drug Entry
- Prucalopride
Prucalopride is a dihydrobenzofurancarboxamide derivative from the benzofurane family that selectively stimulates 5-HT4 receptors and thus, it presents enterokinetic properties.2 The high selectivity of prucalopride allowed further development as it prevented the cardiac adverse reactions observed due to non-target effects of precedent therapies.5 Prucalopride was developed by Shire Development LLC and approved for use in Europe in 2009,1 in Canada on December 7, 2011 and by the FDA on December 17, 2018.7
- Accession Number
- DBSALT002626
- Structure
Structure for Prucalopride succinate (DBSALT002626)
- Synonyms
- Not Available
- External IDs
- R 108512 / R-108512
- UNII
- 4V2G75E1CK
- CAS Number
- 179474-85-2
- Weight
- Average: 485.96
Monoisotopic: 485.1928781 - Chemical Formula
- C22H32ClN3O7
- InChI Key
- QZRSNVSQLGRAID-UHFFFAOYSA-N
- InChI
- InChI=1S/C18H26ClN3O3.C4H6O4/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14;5-3(6)1-2-4(7)8/h11-12H,2-10,20H2,1H3,(H,21,23);1-2H2,(H,5,6)(H,7,8)
- IUPAC Name
- 4-amino-5-chloro-N-[1-(3-methoxypropyl)piperidin-4-yl]-2,3-dihydro-1-benzofuran-7-carboxamide; butanedioic acid
- SMILES
- OC(=O)CCC(O)=O.COCCCN1CCC(CC1)NC(=O)C1=C2OCCC2=C(N)C(Cl)=C1
- External Links
- ChemSpider
- 8045700
- ChEMBL
- CHEMBL2105748
- Wikipedia
- Prucalopride
- Predicted Properties
Property Value Source Water Solubility 0.129 mg/mL ALOGPS logP 2.09 ALOGPS logP 0.74 Chemaxon logS -3.5 ALOGPS pKa (Strongest Acidic) 14.64 Chemaxon pKa (Strongest Basic) 8.98 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 76.82 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 100.67 m3·mol-1 Chemaxon Polarizability 40.8 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon