Irbesartan hydrochlorideProduct ingredient for Irbesartan
- Name
- Irbesartan hydrochloride
- Drug Entry
- Irbesartan
Irbesartan is an angiotensin receptor blocker (ARB) indicated to treat hypertension or diabetic nephropathy.7,8 It can also be used as part of a combination product with hydrochlorothiazide for patients not well controlled or not expected to be well controlled on monotherapy.8 Unlike angiotensin converting enzyme inhibitors, ARBs are not associated with a dry cough.7,8
Irbesartan was granted FDA approval on 30 September 1997.7,8
- Accession Number
- DBSALT002632
- Structure
Structure for Irbesartan hydrochloride (DBSALT002632)
- Synonyms
- Irbesartan HCl
- UNII
- 3OGC31WUMZ
- CAS Number
- 329055-23-4
- Weight
- Average: 465.0
Monoisotopic: 464.2091373 - Chemical Formula
- C25H29ClN6O
- InChI Key
- ZUYFSRQJPNUOQU-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H28N6O.ClH/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23;/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30);1H
- IUPAC Name
- 2-butyl-3-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1,3-diazaspiro[4.4]non-1-en-4-one hydrochloride
- SMILES
- Cl.CCCCC1=NC2(CCCC2)C(=O)N1CC1=CC=C(C=C1)C1=CC=CC=C1C1=NNN=N1
- External Links
- ChemSpider
- 9743676
- Predicted Properties
Property Value Source Water Solubility 0.00884 mg/mL ALOGPS logP 4.51 ALOGPS logP 5.39 Chemaxon logS -4.7 ALOGPS pKa (Strongest Acidic) 5.85 Chemaxon pKa (Strongest Basic) 4.12 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 87.13 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 136.72 m3·mol-1 Chemaxon Polarizability 47.61 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon