Tafamidis meglumineProduct ingredient for Tafamidis
- Name
- Tafamidis meglumine
- Drug Entry
- Tafamidis
Tafamidis and tafamidis meglumine (FX-1006A) are benzoxazole derivatives1 developed by FoldRX.4 Tafamidis is structurally similar to diflusinal.4
Tafamidis was granted an EMA market authorisation on 16 November 20116 and FDA approval on 3 May 2019.7
- Accession Number
- DBSALT002673
- Structure
Structure for Tafamidis meglumine (DBSALT002673)
- Synonyms
- Tafamidis meglumine
- External IDs
- FX-1006A / FX1006A
- UNII
- ZU7CF08A1A
- CAS Number
- 951395-08-7
- Weight
- Average: 503.33
Monoisotopic: 502.0909711 - Chemical Formula
- C21H24Cl2N2O8
- InChI Key
- DQJDBUPLRMRBAB-WZTVWXICSA-N
- InChI
- InChI=1S/C14H7Cl2NO3.C7H17NO5/c15-9-3-8(4-10(16)6-9)13-17-11-2-1-7(14(18)19)5-12(11)20-13;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-6H,(H,18,19);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
- IUPAC Name
- (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol; 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid
- SMILES
- CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)C1=CC=C2N=C(OC2=C1)C1=CC(Cl)=CC(Cl)=C1
- External Links
- ChemSpider
- 28530820
- ChEBI
- 79345
- ChEMBL
- CHEMBL2105675
- Wikipedia
- Tafamidis
- Predicted Properties
Property Value Source Water Solubility 0.0323 mg/mL ALOGPS logP 3.91 ALOGPS logP 4.21 Chemaxon logS -4 ALOGPS pKa (Strongest Acidic) 3.6 Chemaxon pKa (Strongest Basic) -0.4 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 63.33 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 84.69 m3·mol-1 Chemaxon Polarizability 29.74 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon