Talazoparib tosylateProduct ingredient for Talazoparib
- Name
- Talazoparib tosylate
- Drug Entry
- Talazoparib
Talazoparib is an inhibitor of mammalian polyadenosine 5’-diphosphoribose polymerases (PARPs), enzymes responsible for regulating essential cellular functions, such as DNA transcription and DNA repair.4
Developed by Pfizer, talazoparib was first approved by the FDA in October 2018 2 and by the EMA in June 2019.5 It was approved by Health Canada in September 2020.6 Talazoparib is currently used in the treatment of BRCA-mutated breast cancer and HRR-mutated prostate cancer.4,6,7
- Accession Number
- DBSALT002816
- Structure
Structure for Talazoparib tosylate (DBSALT002816)
- Synonyms
- Not Available
- External IDs
- BMN 673TS / BMN-673TS
- UNII
- 02WK9U5NZC
- CAS Number
- 1373431-65-2
- Weight
- Average: 552.56
Monoisotopic: 552.139130712 - Chemical Formula
- C26H22F2N6O4S
- InChI Key
- QUQKKHBYEFLEHK-QNBGGDODSA-N
- InChI
- InChI=1S/C19H14F2N6O.C7H8O3S/c1-27-18(22-8-23-27)15-16(9-2-4-10(20)5-3-9)24-13-7-11(21)6-12-14(13)17(15)25-26-19(12)28;1-6-2-4-7(5-3-6)11(8,9)10/h2-8,15-16,24H,1H3,(H,26,28);2-5H,1H3,(H,8,9,10)/t15-,16-;/m1./s1
- IUPAC Name
- (11S,12R)-7-fluoro-11-(4-fluorophenyl)-12-(1-methyl-1H-1,2,4-triazol-5-yl)-2,3,10-triazatricyclo[7.3.1.0^{5,13}]trideca-1,5,7,9(13)-tetraen-4-one; 4-methylbenzene-1-sulfonic acid
- SMILES
- CC1=CC=C(C=C1)S(O)(=O)=O.CN1N=CN=C1[C@@H]1[C@H](NC2=C3C1=NNC(=O)C3=CC(F)=C2)C1=CC=C(F)C=C1
- External Links
- ChemSpider
- 32697413
- ChEMBL
- CHEMBL3137318
- Wikipedia
- Talazoparib
- Predicted Properties
Property Value Source Water Solubility 0.101 mg/mL ALOGPS logP 2.93 ALOGPS logP 2.11 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 9.48 Chemaxon pKa (Strongest Basic) 1.45 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 84.2 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 111.27 m3·mol-1 Chemaxon Polarizability 35.82 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon