Solriamfetol hydrochlorideProduct ingredient for Solriamfetol
- Name
- Solriamfetol hydrochloride
- Drug Entry
- Solriamfetol
Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apneaLabel. Solriamfetol was given FDA approval in 2019Label.
- Accession Number
- DBSALT002865
- Structure
- Synonyms
- Solriamfetol HCl / Solriamfetol hydrochloride
- UNII
- K7RO88SP7A
- CAS Number
- 178429-65-7
- Weight
- Average: 230.69
Monoisotopic: 230.0822054 - Chemical Formula
- C10H15ClN2O2
- InChI Key
- KAOVAAHCFNYXNJ-SBSPUUFOSA-N
- InChI
- InChI=1S/C10H14N2O2.ClH/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H2,12,13);1H/t9-;/m1./s1
- IUPAC Name
- (2R)-2-amino-3-phenylpropyl carbamate hydrochloride
- SMILES
- Cl.N[C@@H](COC(N)=O)CC1=CC=CC=C1
- External Links
- ChemSpider
- 57617663
- Predicted Properties
Property Value Source Water Solubility 1.95 mg/mL ALOGPS logP 0.62 ALOGPS logP 0.86 Chemaxon logS -2 ALOGPS pKa (Strongest Acidic) 15.68 Chemaxon pKa (Strongest Basic) 9.08 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 78.34 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 53.08 m3·mol-1 Chemaxon Polarizability 20.64 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon