Solriamfetol hydrochlorideProduct ingredient for Solriamfetol

Name
Solriamfetol hydrochloride
Drug Entry
Solriamfetol

Solriamfetol marketed under the brand name Sunosi by Jazz Pharmaceuticals in the United States is a dopamine and norepinephrine reuptake inhibitor (DNRI) indicated in treating daytime sleepiness associated with narcolepsy or obstructive sleep apneaLabel. Solriamfetol was given FDA approval in 2019Label.

Accession Number
DBSALT002865
Structure
Synonyms
Solriamfetol HCl / Solriamfetol hydrochloride
UNII
K7RO88SP7A
CAS Number
178429-65-7
Weight
Average: 230.69
Monoisotopic: 230.0822054
Chemical Formula
C10H15ClN2O2
InChI Key
KAOVAAHCFNYXNJ-SBSPUUFOSA-N
InChI
InChI=1S/C10H14N2O2.ClH/c11-9(7-14-10(12)13)6-8-4-2-1-3-5-8;/h1-5,9H,6-7,11H2,(H2,12,13);1H/t9-;/m1./s1
IUPAC Name
(2R)-2-amino-3-phenylpropyl carbamate hydrochloride
SMILES
Cl.N[C@@H](COC(N)=O)CC1=CC=CC=C1
ChemSpider
57617663
Predicted Properties
PropertyValueSource
Water Solubility1.95 mg/mLALOGPS
logP0.62ALOGPS
logP0.86Chemaxon
logS-2ALOGPS
pKa (Strongest Acidic)15.68Chemaxon
pKa (Strongest Basic)9.08Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area78.34 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity53.08 m3·mol-1Chemaxon
Polarizability20.64 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon