Zinc gluconate trihydrateProduct ingredient for Zinc gluconate
- Name
- Zinc gluconate trihydrate
- Drug Entry
- Zinc gluconate
Zinc gluconate is a zinc salt of gluconic acid comprised of two gluconic acid molecules for each zinc cation (2+). Zinc gluconate is a generally recognized as safe (GRAS) substance by FDA 9. It is available as a trace mineral supplement and over the counter as a lozenge form for a reduced duration of common colds and with decreased symptom severity.
Although it has been nasally administered for treating the common cold, this route of administration has been associated with some cases of anosmia 5, 1, 2, 7.
Studies show that zinc may be better absorbed in humans in the gluconate form 4, 19, however, results from other studies may vary.6,10
Interestingly, zinc supplementation has become a critical intervention for treating diarrheal episodes in children. Studies suggest that administration of zinc along with new low osmolarity oral rehydration solutions/salts (oral rehydration solution), may reduce both the duration and severity of diarrheal episodes for up to 12 weeks 8.
More information about Zinc (in its natural form) is available at Zinc.
- Accession Number
- DBSALT002891
- Structure
Structure for Zinc gluconate trihydrate (DBSALT002891)
- Synonyms
- Not Available
- UNII
- F2F0XU34WQ
- CAS Number
- 12389-19-4
- Weight
- Average: 509.72
Monoisotopic: 508.061791 - Chemical Formula
- C12H28O17Zn
- InChI Key
- ZPQPBMFYUZNVPE-BMDZSJGYSA-L
- InChI
- InChI=1S/2C6H12O7.3H2O.Zn/c2*7-1-2(8)3(9)4(10)5(11)6(12)13;;;;/h2*2-5,7-11H,1H2,(H,12,13);3*1H2;/q;;;;;+2/p-2/t2*2-,3-,4+,5-;;;;/m11..../s1
- IUPAC Name
- zinc(2+) bis(2,3,4,5,6-pentahydroxyhexanoate) trihydrate
- SMILES
- O.O.O.[Zn++].[H]C(O)(CO)C([H])(O)C([H])(O)C([H])(O)C([O-])=O.[H]C(O)(CO)C([H])(O)C([H])(O)C([H])(O)C([O-])=O
- External Links
- ChemSpider
- 32699535
- Predicted Properties
Property Value Source Water Solubility 40.0 mg/mL ALOGPS logP -2 ALOGPS logP -3.4 Chemaxon logS -1.1 ALOGPS pKa (Strongest Acidic) 3.39 Chemaxon pKa (Strongest Basic) -3 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 141.28 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 49.11 m3·mol-1 Chemaxon Polarizability 16.55 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon