Manidipine dihydrochlorideProduct ingredient for Manidipine
- Name
- Manidipine dihydrochloride
- Drug Entry
- Manidipine
Manidipine (INN) is a calcium channel blocker (dihydropyridine type) that is used clinically as an antihypertensive. It is selective for vasculature and does not produce effects on the heart at clinically relevant dosages.
- Accession Number
- DBSALT002895
- Structure
Structure for Manidipine dihydrochloride (DBSALT002895)
- Synonyms
- Manidipine dihydrochloride / Manidipine HCl
- External IDs
- CV 4093 / CV-4093 / CV4093
- UNII
- ZL507UZ6QL
- CAS Number
- 89226-75-5
- Weight
- Average: 683.63
Monoisotopic: 682.2324904 - Chemical Formula
- C35H40Cl2N4O6
- InChI Key
- JINNGBXKBDUGQT-UHFFFAOYSA-N
- InChI
- InChI=1S/C35H38N4O6.2ClH/c1-24-30(34(40)44-3)32(28-15-10-16-29(23-28)39(42)43)31(25(2)36-24)35(41)45-22-21-37-17-19-38(20-18-37)33(26-11-6-4-7-12-26)27-13-8-5-9-14-27;;/h4-16,23,32-33,36H,17-22H2,1-3H3;2*1H
- IUPAC Name
- 3-{2-[4-(diphenylmethyl)piperazin-1-yl]ethyl} 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate dihydrochloride
- SMILES
- Cl.Cl.COC(=O)C1=C(C)NC(C)=C(C1C1=CC(=CC=C1)N(=O)=O)C(=O)OCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=CC=C1
- External Links
- ChemSpider
- 132878
- ChEBI
- 31800
- ChEMBL
- CHEMBL2362693
- Predicted Properties
Property Value Source Water Solubility 0.000995 mg/mL ALOGPS logP 5.11 ALOGPS logP 5.19 Chemaxon logS -5.8 ALOGPS pKa (Strongest Acidic) 16.97 Chemaxon pKa (Strongest Basic) 7.89 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 116.93 Å2 Chemaxon Rotatable Bond Count 12 Chemaxon Refractivity 175.13 m3·mol-1 Chemaxon Polarizability 65.72 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon