Camostat mesilateProduct ingredient for Camostat
- Name
- Camostat mesilate
- Drug Entry
- Camostat
Camostat mesylate, or FOY-305, is a synthetic serine protease inhibitor.2,4 It was first described in the literature in 1981, as part of research on the inhibition of skin tumors in mice.8 Camostat mesylate inhibits cholecystokinin, pro-inflammatory cytokines, and serine proteases, leading to it being investigated for multiple indications including the treatment of COVID-19.6,7,1
Camostat mesylate was first approved in Japan in January 2006.9
- Accession Number
- DBSALT002914
- Structure
Structure for Camostat mesilate (DBSALT002914)
- Synonyms
- Camostat mesilate / Camostat mesylate / Camostat monomethanesulfonate
- External IDs
- FOY 305
- UNII
- 451M50A1EQ
- CAS Number
- 59721-29-8
- Weight
- Average: 494.52
Monoisotopic: 494.147134987 - Chemical Formula
- C21H26N4O8S
- InChI Key
- FSEKIHNIDBATFG-UHFFFAOYSA-N
- InChI
- InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
- IUPAC Name
- [amino({4-[(4-{2-[(dimethylcarbamoyl)methoxy]-2-oxoethyl}phenoxy)carbonyl]phenyl}amino)methylidene]azanium methanesulfonate
- SMILES
- CS([O-])(=O)=O.CN(C)C(=O)COC(=O)CC1=CC=C(OC(=O)C2=CC=C(NC(N)=[NH2+])C=C2)C=C1
- External Links
- ChemSpider
- 39251
- ChEBI
- 31347
- ChEMBL
- CHEMBL85164
- Wikipedia
- Camostat
- Predicted Properties
Property Value Source Water Solubility 0.0255 mg/mL ALOGPS logP 1.35 ALOGPS logP 1.51 Chemaxon logS -4.3 ALOGPS pKa (Strongest Acidic) 19.54 Chemaxon pKa (Strongest Basic) 8.54 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 136.55 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 118.57 m3·mol-1 Chemaxon Polarizability 42.24 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon