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The human von Willebrand factor (vWF) is a human plasma-derived vWF, an endogenous large multimeric plasma glycoprotein involved in hemostasis. It serves a dual role in hemostasis by mediating platelet adhesion and aggregation at the site of blood vessel injury and stabilizing procoagulant factor VIII (FVIII). Exogenous sources of vWF...
Approved
Investigational
Matched Synonyms: … Human von willebrand factor ... Von willebrand factor (human) ... von Willebrand factor, human
Matched Name: … Von Willebrand factor human
Matched Description: … The human von Willebrand factor (vWF) is a human plasma-derived vWF, an endogenous large multimeric plasma ... The human vWF is used to manage and control bleeding episodes in patients with von Willebrand disease ... vWF products are also available as a combination product with [antihemophilic factor human]. …
Matched Mixtures name: … von Willebrand Factor/Coagulation Factor VIII Complex (Human) ... von Willebrand Factor/Coagulation Factor VIII Complex (Human) ... Wilate - von Willebrand Factor/Coagulation Factor VIII Complex (Human) …
Matched Categories: … von Willebrand factor and coagulation factor VIII in combination ... von Willebrand Factor ... von Willebrand factor ... von Willebrand Factor, antagonists & inhibitors ... Blood and Blood Forming Organs …
Matched Products: … IMMUNATE 50 IU/ML POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... IMMUNATE 100 IU/ML POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Antihemophilic factor human, also known as Coagulation Factor VIII or Anti-Hemophilic Factor (AHF), is a non-recombinant, lyophilized concentrate of coagulation factor VIII, an endogenous protein and essential component of the coagulation cascade. Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) and purified from extraneous plasma-derived...
Approved
Matched Synonyms: … Antihemophilic factor, human ... Antihemophilic factor,human ... Antihemophilic factor VIII human
Matched Name: … Antihemophilic factor human
Matched Description: … Antihemophilic factor is manufactured with reduced amounts of von Willebrand Factor antigen (VWF:Ag) ... Antihemophilic factor human is approved by the Food and Drug Administration for use in hemophilia A ( ... Other drug products with similar structure and function to Antihemophilic factor human include [DB13999 …
Matched Mixtures name: … von Willebrand Factor/Coagulation Factor VIII Complex (Human) ... von Willebrand Factor/Coagulation Factor VIII Complex (Human) ... Wilate - von Willebrand Factor/Coagulation Factor VIII Complex (Human) …
Matched Categories: … Human Antihemophilic Factors ... Factor VIII ... coagulation factor VIII ... Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Matched Products: … FACTOR VIII 500 IU FLAKON, 1 ADET ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 500 IU ... NUWIQ POWDER AND SOLVENT FOR SOLUTION FOR INJECTION 250 IU …
Approved
Investigational
Matched Synonyms: … Factor VIII …
Matched Categories: … Human Antihemophilic Factors ... Factor VIII ... Amino Acids, Peptides, and Proteins …
Matched Products: … DRIED FACTOR VIII FRACTION 500 UI + FACTOR DE VON WILLEBRAND 800 UI ... HEMOFIL M ANTIHEMOPHILIC FACTOR (HUMAN), METHOD M, ... ANTIHEMOPHILIC FACTOR (HUMAN) HEMOFIL M METHOD M, MONOCLONAL PURIFIED FVIII …
Moroctocog alfa, also known as BDDrFVIII (B domain deleted recombinant factor VIII), is a recombinant DNA-based drug with functional characteristics comparable to those of endogenous coagulation Factor VIII, the essential human blood clotting protein that is impaired in Hemophilia A. Moroctocog alfa is identical in sequence to endogenously produced Factor...
Approved
Matched Synonyms: … Human factor VIII, recombinant B-domain deleted ... Antihemophilic factor recombinant plasma/albumin free ... Antihemphilic factor, recombinant human B-domain deleted …
Matched Description: … As it does not contain von Willebrand factor it is not indicated in von Willebrand’s disease [FDA Label ... purified Factor VIII from human pooled blood and contains both A- and B-subunits, and [DB11607], which ... factor VIII due to conjugation to the dimeric Fc domain of human immunoglobulin G1, a long-lived plasma …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Matched Products: … Xyntha 250 IU Powder and Solvent for Solution for Injection ... Xyntha 1000 IU Powder and Solvent for Solution for Injection ... Xyntha 500 IU Powder and Solvent for Solution for Injection …
Efmoroctocog alfa is a fully recombinant factor VIII-Fc fusion protein (rFVIIIFc) with an extended half-life compared with conventional factor VIII (FVIII) preparations, including recombinant FVIII (rFVIII) products such as DB13999 . It is an antihemorrhagic agent used in replacement therapy for patients with haemophilia A (congenital factor VIII deficiency). It...
Approved
Investigational
Matched Synonyms: … Antihemophilic factor (recombinant, FC fusion protein) ... Antihemophilic Factor (Recombinant BDD), FC Fusion Protein ... Coagulation factor VIII recombinant immunoglubulin g1 fusion protein …
Matched Description: … is purified endogenous Factor VIII from human pooled blood and contains both A- and B-subunits. ... is produced by recombinant DNA technology and is identical in sequence to endogenously produced Factor ... conjugated molecule of rFVIII to polyethylene glycol is covalently fused to the dimeric Fc domain of human
Matched Categories: … Human Antihemophilic Factors …
Intravenous susoctocog alfa is a recombinant, B-domain deleted, porcine sequence antihaemophilic factor VIII (FVIII) product that has recently been approved for the treatment of bleeding episodes in adults with acquired haemophilia A (AHA). AHA is a rare bleeding disorder that results in a prolonged clotting time as measured by the...
Approved
Investigational
Matched Synonyms: … Antihemophilic factor (recombinant) porcine sequence ... ANTIHEMOPHILIC FACTOR (RECOMBINANT), PORCINE SEQUENCE ... Antihemophilic factor porcine, B-domain truncated recombinant …
Matched Description: … These autoantibodies neutralize circulating human factor VIII and create a functional deficiency of this ... The recombinant porcine sequence allows less susceptibility to inactivation by circulating human factor ... directed against Factor VIII. …
Matched Categories: … Blood and Blood Forming Organs …
Antihemophilic Factor (Recombinant), PEGylated, was approved by the FDA in December 2016 as the product Adynovate [FDA label]. Antihemophilic Factor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor VIII (2,332 amino acids with a molecular weight (MW) of approximately 280 kDa) covalently conjugated with at least one molecule of...
Approved
Investigational
Matched Synonyms: … Antihemophilic Factor (Recombinant), PEGylated ... antihemophilic factor (recombinant), PEGylated-aucl …
Matched Name: … Antihemophilic factor (recombinant), PEGylated …
Matched Description: … Antihemophilic Factor (Recombinant), PEGylated, is a recombinant full-length human coagulation factor ... Antihemophilic Factor (Recombinant), PEGylated, was approved by the FDA in December 2016 as the product ... PEGylation decreases factor VIII clearance and allowing for an increased duration of drug circulation …
Matched Categories: … Human Antihemophilic Factors ... Amino Acids, Peptides, and Proteins …
Matched Products: … ADYNOVATE 3000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 250 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION ... ADYNOVATE 1000 IU POWDER AND SOLVENT FOR SOLUTION FOR INJECTION …
Turoctocog alfa pegol is a pegylated version of turoctocog alfa. Novo Nordisk's brand name Esperoct (turoctocog alfa pegol, N8-GP) was approved by the US FDA on February 19, 2019. Fundamentally, the N8-GP moiety is identical to turoctocog alfa, a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made...
Approved
Matched Synonyms: … Antihemophilic factor (recombinant), glycopegylated-exei …
Matched Description: … Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor ... VIII molecule for factor VIII replacement therapy in patients with factor VIII deficiency, or hemophilia ... Turoctocog alfa is produced in Chinese hamster ovary (CHO) cells without addition of any human or animal-derived …
Matched Categories: … Factor VIII ... Amino Acids, Peptides, and Proteins …
Thrombotic thrombocytopenic purpura (TTP) is a rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and various degrees of organ damage. It may be inherited (congenital TTP; cTTP) or acquired due to autoantibodies (immune-mediated TTP; iTTP), although cTTP accounts for <5% of all cases of TTP. Patients with cTTP...
Approved
Investigational
Matched Synonyms: … Recombinant disintegrin and metalloprotease with thrombospondin type 1 motifs ... Recombinant human adamts13 ... Metalloproteinase ADAMTS13 (human recombinant BAX930) …
Matched Description: … Willebrand factor multimers and preventing the formation of microthrombi - this deficiency in ADAMTS13 ... metalloproteinase with a thrombospondin type 1 motif, member 13), which is responsible for cleaving large von ... rare blood clotting disorder characterized by thrombocytopenia, microangiopathic hemolytic anemia, and
Matched Categories: … Enzymes and Coenzymes ... Amino Acids, Peptides, and Proteins …
Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration . It was initially approved by the FDA in 1991 . It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for...
Approved
Matched Description: … It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be ... used instead of other macrolides for some sexually transmitted and enteric infections. ... Azithromycin is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue …
Matched Categories: … cefixime and azithromycin ... azithromycin, fluconazole and secnidazole ... Macrolides, Lincosamides and Streptogramins …
Matched Products: … ZITHROMAX KDR VON 26-45KG …
Vonicog alfa is a recombinant von Willebrand factor manufactured by Baxalta. It was FDA approved in December 2015. The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg. By the EMA, vonicog alfa is still under clinical analysis.
Approved
Investigational
Matched Synonyms: … Von willebrand factor, recombinant, human ... Von willebrand factor (recombinant) …
Matched Description: … [A32230] The gen of von Willebrand factor was first cloned in 1985 by Stuart Orkin and David Ginsburg ... Vonicog alfa is a recombinant von Willebrand factor manufactured by Baxalta. …
Simoctocog alfa is a recombinant B-domain deleted (BDD) rFVIII produced in genetically modified human embryonic kidney (HEK) 293F cells. The harvested product is concentrated and purified by a series of chromatography steps. It is an antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the...
Approved
Matched Description: … patterns found in non-human cell lines led to decreased immunogenicity and longer half-life [A31525]. ... antihemorrhagic agent used as a replacement therapy in individuals with Haemophilia A who lack the factor ... The harvested product is concentrated and purified by a series of chromatography steps. …
Matched Categories: … Amino Acids, Peptides, and Proteins …
Desmopressin (dDAVP), a synthetic analogue of 8-arginine vasopressin (ADH), is an antidiuretic peptide drug modified by deamination of 1-cysteine and substitution of 8-L-arginine by 8-D-arginine. ADH is an endogenous pituitary hormone that has a crucial role in the control of the water content in the body. Upon release from the...
Approved
Matched Description: … It was also newly approved for the treatment of mild classical hemophilia and von Willebrand's disease ... solution, intravenous solution, oral tablet and oral lyophilisate [A31662]. ... a prolonged half-life and duration of action compared to endogenous ADH [A31661]. …
Matched Categories: … Factor VIII Activator ... Increased Coagulation Factor VIII Activity ... Increased Coagulation Factor VIII Concentration ... Pituitary and Hypothalamic Hormones and Analogues ... Sex Hormones and Insulins …
Vonoprazan is a potassium-competitive acid blocker (PCAB) that inhibits H+, K+-ATPase-mediated gastric acid secretion. PCABs represent an alternative to proton-pump inhibitors for the treatment of acid-related disorders. Unlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require acid-resistant formulations. Furthermore, vonoprazan is 350-times more potent...
Approved
Investigational
Matched Description: … Unlike proton-pump inhibitors, PCABs are not affected by CYP2C19 genetic polymorphisms and do not require ... In February 2015, vonoprazan was first marketed in Japan for the treatment of acid-related disorders and ... In May 2022, the FDA approved the use of vonoprazan in a co-packaged product containing amoxicillin and
Matched Categories: … Alimentary Tract and Metabolism ... vonoprazan, amoxicillin and metronidazole ... vonoprazan, amoxicillin and clarithromycin ... Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) …
Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin inhibitor dabigatran.[A177463, A6970, L34675, L34680] Dabigatran etexilate may be used to decrease the risk of venous thromboembolic events in patients in whom anticoagulation therapy is indicated. In contrast to warfarin, because its anticoagulant effects...
Approved
Matched Description: … Dabigatran etexilate is an oral prodrug that is hydrolyzed to the competitive and reversible direct thrombin …
Matched Categories: … Blood and Blood Forming Organs …
Neomycin is a broad-spectrum aminoglycoside antibiotic drug that is derived from the metabolic products of Streptomyces fradiae. Neomycin is a complex comprised of three components, neomycin A, B, and C. Neomycin B, also known as framycetin, is the most active component of the complex and neomycin C is the isomer...
Approved
Vet approved
Matched Description: … [A175042] Neomycin is active against both gram-positive and gram-negative organisms and mediates its ... [L11979] Neomycin is a complex comprised of three components, neomycin A, B, and C. ... preparations for use in the treatment of inflammatory conditions and infections in the eye. …
Matched Mixtures name: … Welly Human Repair Kit ... Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ... Neomycin and Polymyxin B Sulfates and Dexamethasone …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions ... Ophthalmological and Otological Preparations ... Antiinfectives and Antiseptics for Local Oral Treatment …
Sodium chloride, also known as salt, common salt, table salt or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular organisms. It is listed...
Approved
Vet approved
Matched Description: … or halite, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and ... Sodium chloride is the primary salt in seawater and in the extracellular fluid of many multicellular …
Matched Mixtures name: … Albumin Human Diluent ... Plasma-Lyte 148 and dextrose ... Ringers and Dextrose …
Matched Categories: … Alimentary Tract and Metabolism ... Blood and Blood Forming Organs ... Blood Substitutes and Perfusion Solutions …
Matched Products: … Walgreens Infants and Childrens Saline Nasal ... Natriumchlorid Noridem 0,9 % Injektionslösung oder Lösungsmittel zur Herstellung von Parenteralia …
Efanesoctocog alfa (BIVV001) is a recombinant factor VIII (FVIII) analogue fusion protein used for the routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding episodes in patients with hemophilia A. The use of FVIII replacement products is beneficial in patients with hemophilia A; however, their quality...
Approved
Investigational
Matched Synonyms: … Antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl …
Matched Description: … ceiling to which other forms of recombinant FVIII are subjected due to their association with von Willebrand ... factor (VWF). ... routine prophylaxis, perioperative management of bleeding and on-demand treatment and control of bleeding …
Matched Categories: … Factor VIII ... Amino Acids, Peptides, and Proteins …
Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation. Derived from venom of the Southeastern pygmy rattlesnake (Sistrurus miliarus barbouri), eptifibatide is a cyclic heptapeptide that belongs to the class of arginin-glycin-aspartat-mimetics.
Approved
Investigational
Matched Description: … Synthetic cyclic hexapeptide that binds to platelet receptor glycoprotein and inhibits platelet aggregation …
Matched Categories: … Blood and Blood Forming Organs ... Amino Acids, Peptides, and Proteins …
Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (αvβ3) receptor found on platelets...
Approved
Matched Description: … by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. ... Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation ... Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. …
Matched Categories: … Amino Acids, Peptides, and Proteins ... Blood and Blood Forming Organs …
Piracetam is a nootropic drug in the racetams group, with chemical name 2-oxo-1-pyrrolidine acetamide. It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative of the neurotransmitter γ-aminobutyric acid (GABA). However its mechanism of action differ from that of endogenous GABA. Piracetam has neuroprotective and...
Approved
Investigational
Matched Description: … Piracetam has neuroprotective and anticonvulsant properties and is reported to improve neural plasticity ... It shares the same 2-oxo-pyrrolidone base structure with pyroglutamic acid and is a cyclic derivative ... Its efficacy is documented in cognitive disorders and dementia, vertigo, cortical myoclonus, dyslexia …
Matched Categories: … Psychostimulants, Agents Used for ADHD and Nootropics …
Vonlerolizumab is under investigation in clinical trial NCT03029832 (A Study of MOXR0916 in Combination With Atezolizumab Versus Atezolizumab Alone in Participants With Untreated Locally Advanced or Metastatic Urothelial Carcinoma Who Are Ineligible for Cisplatin-based Therapy).
Investigational
Matched Synonyms: … Immunoglobulin g1-kappa, anti-(human tumor necrosis factor receptor superfamily member 4 (act35 antigen ... Immunoglobulin g1-kappa, anti-(homo sapiens tnfrsf4(tumor necrosis factor receptor (tnfr) superfamily …
Matched Categories: … Amino Acids, Peptides, and Proteins …
TT 173 is a Modified Human Tissue Factor currently being investigated to treat bleeding disorders such as hemophilia and von Willebrand disease, as well as bleeding episodes in cutaneous injuries or dental procedures.
Investigational
Matched Description: … as hemophilia and von Willebrand disease, as well as bleeding episodes in cutaneous injuries or dental ... TT 173 is a Modified Human Tissue Factor currently being investigated to treat bleeding disorders such …
Displaying all 23 drugs