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Displaying all 3 drugs
Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class. It was developed by Vertex Pharmaceuticals and FDA approved in combination with ivacaftor to manage cystic fibrosis. This drug was approved by the FDA on February 12, 2018. Cystic Fibrosis is an autosomal recessive disorder caused...
Approved
Investigational
Matched Synonyms: … Tezacaftor
Matched Name: … Tezacaftor
Matched Description: … [L1595] It was developed by Vertex Pharmaceuticals and FDA approved in combination with [ivacaftor] to ... Tezacaftor is a drug of the cystic fibrosis transmembrane conductance regulator (CFTR) potentiator class ... consequently abnormal fluid and ion transport across cell membranes. …
Matched Categories: … ivacaftor, tezacaftor and elexacaftor ... ivacaftor and tezacaftor
Elexacaftor (previously VX-445) is a small molecule, next-generation corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) protein. It received FDA approval in October 2019 in combination with tezacaftor and ivacaftor as the combination product TrikaftaTM. Elexacaftor is considered a next-generation CFTR corrector as it possesses both a different structure...
Approved
Investigational
Matched Synonyms: … Elexacaftor
Matched Name: … Elexacaftor
Matched Description: … [A187361] It received FDA approval in October 2019 in combination with [tezacaftor] and [ivacaftor] as ... proteins unresponsive to ivacaftor or tezacaftor. ... and mechanism as compared to first generation correctors like tezacaftor. …
Matched Categories: … ivacaftor, tezacaftor and elexacaftor
Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. It was approved by the Food and Drug Administration on January 31, 2012 , and by Health Canada in late 2012. Ivacaftor is administered...
Approved
Matched Synonyms: … Ivacaftor
Matched Name: … Ivacaftor
Matched Description: … [L6841] Ivacaftor is administered as a monotherapy and also administered in combination with other drugs ... Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF ... [A20302] Prior to the development of ivacaftor, management of CF primarily involved therapies for …
Matched Categories: … ivacaftor, tezacaftor and elexacaftor ... ivacaftor and tezacaftor ... ivacaftor and lumacaftor ... ivacaftor
Displaying all 3 drugs