NAV

Mebrofenin

This drug entry is a stub and has not been fully annotated. It is scheduled to be annotated soon.

Identification

Brand Names
Choletec
Generic Name
Mebrofenin
DrugBank Accession Number
DB15779
Background

Not Available

Type
Small Molecule
Groups
Approved, Experimental
Structure
3D
Similar Structures
Weight
Average: 387.23
Monoisotopic: 386.047735
Chemical Formula
C15H19BrN2O5
Synonyms
  • Mebrofenin
  • Mebrofenine
  • Mebrofenino
  • Mebrofeninum
External IDs
  • SQ 26962
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Pharmacology

Indication

Not Available

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Associated Conditions
Indication TypeIndicationCombined Product DetailsApproval LevelAge GroupPatient CharacteristicsDose Form
Diagnostic agentBile duct disorders•••••••••••••••••••••• ••••••• •••••••••••• ••• ••••••••
Contraindications & Blackbox Warnings
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Pharmacodynamics

Not Available

Mechanism of action
Not Available
Absorption

Not Available

Volume of distribution

Not Available

Protein binding

Not Available

Metabolism
Not Available
Route of elimination

Not Available

Half-life

Not Available

Clearance

Not Available

Adverse Effects
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Toxicity

Not Available

Pathways
Not Available
Pharmacogenomic Effects/ADRs
Not Available

Interactions

Drug Interactions
This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Not Available
Food Interactions
Not Available

Products

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Brand Name Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
CholetecInjection, powder, lyophilized, for solution45 mg/1IntravenousBracco Diagnostics Inc1987-01-21Not applicableUS flag
MebrofeninInjection, powder, lyophilized, for solution10 mg/1IntravenousAnazaoHealth Corporation2012-06-19Not applicableUS flag
Generic Prescription Products
NameDosageStrengthRouteLabellerMarketing StartMarketing EndRegionImage
Kit for the Preparation of Technetium Tc 99m MebrofeninInjection, powder, lyophilized, for solution45 mg/10mLIntravenousSun Pharmaceutical Industries, Inc.2008-01-29Not applicableUS flag
Unapproved/Other Products
NameIngredientsDosageRouteLabellerMarketing StartMarketing EndRegionImage
MebrofeninMebrofenin (10 mg/1)Injection, powder, lyophilized, for solutionIntravenousAnazaoHealth Corporation2012-06-19Not applicableUS flag

Categories

Drug Categories
Classification
Not classified
Affected organisms
Not Available

Chemical Identifiers

UNII
7PV0B6ED98
CAS number
78266-06-5
InChI Key
MHPZZZZLAQGTHT-UHFFFAOYSA-N
InChI
InChI=1S/C15H19BrN2O5/c1-8-4-9(2)15(10(3)14(8)16)17-11(19)5-18(6-12(20)21)7-13(22)23/h4H,5-7H2,1-3H3,(H,17,19)(H,20,21)(H,22,23)
IUPAC Name
2-({[(3-bromo-2,4,6-trimethylphenyl)carbamoyl]methyl}(carboxymethyl)amino)acetic acid
SMILES
CC1=CC(C)=C(Br)C(C)=C1NC(=O)CN(CC(O)=O)CC(O)=O

References

General References
Not Available
ChemSpider
48922
RxNav
1311500
ChEBI
135608
ChEMBL
CHEMBL1605443
ZINC
ZINC000000537957
Wikipedia
Technetium_(99mTc)_mebrofenin

Clinical Trials

Clinical Trials
PhaseStatusPurposeConditionsCount
1CompletedBasic ScienceNon Alcoholic Steatohepatitis (NASH)1

Pharmacoeconomics

Manufacturers
Not Available
Packagers
Not Available
Dosage Forms
FormRouteStrength
Injection, powder, lyophilized, for solutionIntravenous45 mg/1
Injection, powder, lyophilized, for solutionIntravenous45 mg/10mL
Injection, powder, lyophilized, for solutionIntravenous10 mg/1
Injection, powder, lyophilized, for solutionIntravenous20 mg
Prices
Not Available
Patents
Not Available

Properties

State
Not Available
Experimental Properties
Not Available
Predicted Properties
PropertyValueSource
Water Solubility0.0568 mg/mLALOGPS
logP-0.39ALOGPS
logP-0.42Chemaxon
logS-3.8ALOGPS
pKa (Strongest Acidic)2.81Chemaxon
pKa (Strongest Basic)2.14Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count6Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area106.94 Å2Chemaxon
Rotatable Bond Count7Chemaxon
Refractivity89.27 m3·mol-1Chemaxon
Polarizability35.27 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon
Predicted ADMET Features
Not Available

Spectra

Mass Spec (NIST)
Not Available
Spectra
SpectrumSpectrum TypeSplash Key
Predicted MS/MS Spectrum - 10V, Positive (Annotated)Predicted LC-MS/MSsplash10-00kr-0319000000-47285fb2023f199ea9a6
Predicted MS/MS Spectrum - 10V, Negative (Annotated)Predicted LC-MS/MSsplash10-01ti-7094000000-80a859782faaf2f7938c
Predicted MS/MS Spectrum - 20V, Negative (Annotated)Predicted LC-MS/MSsplash10-004i-9210000000-d4e9134a924613dfeb25
Predicted MS/MS Spectrum - 20V, Positive (Annotated)Predicted LC-MS/MSsplash10-0j4i-0292000000-d0ab414d0d9378c069fc
Predicted MS/MS Spectrum - 40V, Negative (Annotated)Predicted LC-MS/MSsplash10-000l-9060000000-0277d06beaad7828c0d3
Predicted MS/MS Spectrum - 40V, Positive (Annotated)Predicted LC-MS/MSsplash10-01rj-3890000000-514496989806c097e400
Predicted 1H NMR Spectrum1D NMRNot Applicable
Predicted 13C NMR Spectrum1D NMRNot Applicable
Chromatographic Properties
Collision Cross Sections (CCS)
AdductCCS Value (Å2)Source typeSource
[M-H]-175.92549
predicted
DeepCCS 1.0 (2019)
[M+H]+178.2835
predicted
DeepCCS 1.0 (2019)
[M+Na]+184.71635
predicted
DeepCCS 1.0 (2019)

Drug created at August 21, 2020 16:56 / Updated at February 21, 2021 18:55