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Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved for the prevention of delayed chemotherapy-induced nausea and vomiting (CINV) in adults. Delayed-phase CINV typically occurs >24 hours after chemotherapy treatment and is principally mediated by Neurokinin-1 and its ligand Substance P, which is released in the gut...
Approved
Investigational
Matched Synonyms: … Rolapitant
Matched Name: … Rolapitant
Matched Description: … , rolapitant prevents late-phase CINV. ... Rolapitant is a potent, highly selective, long-acting Neurokinin-1 (NK-1) receptor antagonist approved ... Unlike other available NK-1 receptor antagonists, rolapitant is not an inhibitor of Cytochrome P450 enzyme …
Matched Salts name: … Rolapitant hydrochloride ... Rolapitant hydrochloride monohydrate …
Matched Categories: … rolapitant ... Antiemetics and Antinauseants ... Alimentary Tract and Metabolism …
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