IdentifierDBSNPE000002, DBSNPE005523
DrugDB00945 (Acetylsalicylic acid)
Interacting Gene/EnzymeCytochrome P450 2C9
Gene NameCYP2C9
UniProt IDP11712
Defining Change(s)
C Allelers1057910
Allele NameCYP2C9*3
Genotype(s)(C;C) / (A;C)
Type(s)Effect Directly Studied
GroupsNon-functional CYP2C9; Decreased CYP2C9
DescriptionPatients with this genotype have reduced metabolism of acetylsalicylic acid.
References
  1. Kirchheiner J, Stormer E, Meisel C, Steinbach N, Roots I, Brockmoller J: Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites. Pharmacogenetics. 2003 Aug;13(8):473-80. [PubMed:12893985 ]