DrugDB00072 (Trastuzumab)
Interacting Gene/EnzymeReceptor tyrosine-protein kinase erbB-2
Gene NameERBB2
UniProt IDP04626
Defining Change(s)
G Allele, heterozygoters1136201
Allele NameNot Available
Type(s)ADR Directly Studied
GroupsNot Available
DescriptionPatients with this genotype have increased risk of cardiotoxicity with trastuzumab.
  1. Beauclair S, Formento P, Fischel JL, Lescaut W, Largillier R, Chamorey E, Hofman P, Ferrero JM, Pages G, Milano G: Role of the HER2 [Ile655Val] genetic polymorphism in tumorogenesis and in the risk of trastuzumab-related cardiotoxicity. Ann Oncol. 2007 Aug;18(8):1335-41. [PubMed:17693647 ]