DrugDB00945 (Acetylsalicylic acid)
Interacting Gene/EnzymeLeukotriene C4 synthase
Gene NameLTC4S
UniProt IDQ16873
Defining Change(s)
C allelers730012
Allele NameNot Available
Genotype(s)(A;C) / (C;C)
Type(s)ADR Directly Studied
GroupsNot Available
DescriptionThe presence of this genotype in LTC4S may indicate an increased risk of chronic urticaria when treated with acetylsalicylic acid.
  1. Mastalerz L, Setkowicz M, Sanak M, Rybarczyk H, Szczeklik A: Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Br J Dermatol. 2006 Feb;154(2):256-60. [PubMed:16433794 ]