Pharmacogenomic Effect/ADR for Acetylsalicylic acid (DBSNPE000099)

Identifier
DBSNPE000099
Drug
DB00945 (Acetylsalicylic acid)
Interacting Gene/Enzyme
Leukotriene C4 synthase
Gene Name
LTC4S
UniProt ID
Q16873
Defining Change(s)
C allelers730012
Allele Name
Not Available
Genotype(s)
(A;C) / (C;C)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this genotype in LTC4S may indicate an increased risk of chronic urticaria when treated with acetylsalicylic acid.
References
  1. Mastalerz L, Setkowicz M, Sanak M, Rybarczyk H, Szczeklik A: Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant. Br J Dermatol. 2006 Feb;154(2):256-60. [PubMed:16433794]