DrugDB00675 (Tamoxifen)
Interacting Gene/EnzymeCoagulation factor V
Gene NameF5
UniProt IDP12259
Defining Change(s)
A allelers6025
Allele NameNot Available
Genotype(s)(A;A) / (A;G)
Type(s)ADR Directly Studied
GroupsNot Available
DescriptionBreast cancer patients taking tamoxifen as part of treatment regimine are more likely to experience a thromboembolic event.
  1. Garber JE, Halabi S, Tolaney SM, Kaplan E, Archer L, Atkins JN, Edge S, Shapiro CL, Dressler L, Paskett ED, Kimmick G, Orcutt J, Scalzo A, Winer E, Levine E, Shahab N, Berliner N: Factor V Leiden mutation and thromboembolism risk in women receiving adjuvant tamoxifen for breast cancer. J Natl Cancer Inst. 2010 Jul 7;102(13):942-9. doi: 10.1093/jnci/djq211. Epub 2010 Jun 16. [PubMed:20554945 ]