Pharmacogenomic Effect/ADR for Tamoxifen (DBSNPE000127)

Identifier
DBSNPE000127
Drug
DB00675 (Tamoxifen)
Interacting Gene/Enzyme
Coagulation factor V
Gene Name
F5
UniProt ID
P12259
Defining Change(s)
A allelers6025
Allele Name
Not Available
Genotype(s)
(A;A) / (A;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients with this genotype have increased risk of a thromboembolic event with tamoxifen.
References
  1. Garber JE, Halabi S, Tolaney SM, Kaplan E, Archer L, Atkins JN, Edge S, Shapiro CL, Dressler L, Paskett ED, Kimmick G, Orcutt J, Scalzo A, Winer E, Levine E, Shahab N, Berliner N: Factor V Leiden mutation and thromboembolism risk in women receiving adjuvant tamoxifen for breast cancer. J Natl Cancer Inst. 2010 Jul 7;102(13):942-9. doi: 10.1093/jnci/djq211. Epub 2010 Jun 16. [PubMed:20554945]