Pharmacogenomic Effect/ADR for Abacavir (DBSNPE000129)

Identifier
DBSNPE000129
Drug
DB01048 (Abacavir)
Interacting Gene/Enzyme
HLA class I histocompatibility antigen protein P5
Gene Name
HCP5
UniProt ID
Q6MZN7
Defining Change(s)
G allelers2395029
Allele Name
HLA-B*5701
Genotype(s)
(G;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
Patients who carry this SNP are at a higher risk of experiencing a hypersensitivity reaction to abacavir.
References
  1. Colombo S, Rauch A, Rotger M, Fellay J, Martinez R, Fux C, Thurnheer C, Gunthard HF, Goldstein DB, Furrer H, Telenti A: The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir. J Infect Dis. 2008 Sep 15;198(6):864-7. doi: 10.1086/591184. [PubMed:18684101]
  2. Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP: HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31. [PubMed:19483685]