IdentifierDBSNPE000129
DrugDB01048 (Abacavir)
Interacting Gene/EnzymeHLA class I histocompatibility antigen protein P5
Gene NameHCP5
UniProt IDQ6MZN7
Defining Change(s)
G allelers2395029
Allele NameHLA-B*5701
Genotype(s)(G;G)
Type(s)ADR Directly Studied
GroupsNot Available
DescriptionPatients who carry this SNP are at a higher risk of experiencing a hypersensitivity reaction to abacavir.
References
  1. Colombo S, Rauch A, Rotger M, Fellay J, Martinez R, Fux C, Thurnheer C, Gunthard HF, Goldstein DB, Furrer H, Telenti A: The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir. J Infect Dis. 2008 Sep 15;198(6):864-7. doi: 10.1086/591184. [PubMed:18684101 ]
  2. Daly AK, Donaldson PT, Bhatnagar P, Shen Y, Pe'er I, Floratos A, Daly MJ, Goldstein DB, John S, Nelson MR, Graham J, Park BK, Dillon JF, Bernal W, Cordell HJ, Pirmohamed M, Aithal GP, Day CP: HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31. [PubMed:19483685 ]