Pharmacogenomic Effect/ADR for Verapamil (DBSNPE000157)

Identifier
DBSNPE000157
Drug
Verapamil (DB00661)
Interacting Gene/Enzyme
Beta-1 adrenergic receptor
Gene Name
ADRB1
UniProt ID
P08588
Defining Change(s)
G > Crs1801253
Allele Name
Not Available
Genotype(s)
(G;G) / (C;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
Patients with this genotype require a lower dosage of verapamil to achieve a favourable rate-control response when treating atrial fibrillation.
References
  1. Parvez B, Chopra N, Rowan S, Vaglio JC, Muhammad R, Roden DM, Darbar D: A common beta1-adrenergic receptor polymorphism predicts favorable response to rate-control therapy in atrial fibrillation. J Am Coll Cardiol. 2012 Jan 3;59(1):49-56. doi: 10.1016/j.jacc.2011.08.061. [PubMed:22192668]