DrugDB08916 (Afatinib)
Interacting Gene/EnzymeEpidermal growth factor receptor
Gene NameEGFR
UniProt IDP00533
Defining Change(s)
G > A or C or Trs28929495
Allele NameG719A/C
Genotype(s)(T;T) / (G;T) / (A;A) / (A;G) / (C;C) / (C;G)
Type(s)Effect Directly Studied
GroupsNot Available
DescriptionThe presence of this polymorphism in EGFR is associated with a higher response rate to afatinib.
  1. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073 ]