Pharmacogenomic Effect/ADR for Afatinib (DBSNPE000202)

Identifier
DBSNPE000202
Drug
DB08916 (Afatinib)
Interacting Gene/Enzyme
Epidermal growth factor receptor
Gene Name
EGFR
UniProt ID
P00533
Defining Change(s)
G > A or C or Trs28929495
Allele Name
G719A/C
Genotype(s)
(T;T) / (G;T) / (A;A) / (A;G) / (C;C) / (C;G)
Type(s)
Effect Directly Studied
Groups
Not Available
Description
The presence of this polymorphism in EGFR is associated with a higher response rate to afatinib.
References
  1. Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. Epub 2004 Apr 29. [PubMed:15118073]