- Identifier
- DBSNPE000262
- Drug
- Lapatinib (DB01259)
- Interacting Gene/Enzyme
- HLA class II histocompatibility antigen, DQ alpha 1 chain
- Gene Name
- HLA-DQA1
- UniProt ID
- P01909
- Defining Change(s)
- Allele Name
- HLA-DQA1*02:01
- Genotype(s)
- Not Available
- Type(s)
- ADR Directly Studied
- Groups
- Not Available
- Description
- The presence of this polymorphism in TNXB may indicate an increased risk of drug-induced ALT-elevations leading to hepatotoxicity when treated with lapatinib.
- References
- Spraggs CF, Budde LR, Briley LP, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR: HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol. 2011 Feb 20;29(6):667-73. doi: 10.1200/JCO.2010.31.3197. Epub 2011 Jan 18. [PubMed:21245432]