DrugDB01259 (Lapatinib)
Interacting Gene/EnzymeHLA class II histocompatibility antigen, DQ alpha 1 chain
Gene NameHLA-DQA1
UniProt IDP01909
Defining Change(s)
HLA-DQA1*02Not Available
Allele NameHLA-DQA1*02:01
Genotype(s)Not Available
Type(s)ADR Directly Studied
GroupsNot Available
DescriptionThe presence of this polymorphism in TNXB may indicate an increased risk of drug-induced ALT-elevations leading to hepatotoxicity when treated with lapatinib.
  1. Spraggs CF, Budde LR, Briley LP, Bing N, Cox CJ, King KS, Whittaker JC, Mooser VE, Preston AJ, Stein SH, Cardon LR: HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer. J Clin Oncol. 2011 Feb 20;29(6):667-73. doi: 10.1200/JCO.2010.31.3197. Epub 2011 Jan 18. [PubMed:21245432 ]