| Identifier | DBSNPE000262 | ||
|---|---|---|---|
| Drug | DB01259 (Lapatinib) | ||
| Interacting Gene/Enzyme | HLA class II histocompatibility antigen, DQ alpha 1 chain | ||
| Gene Name | HLA-DQA1 | ||
| UniProt ID | P01909 | ||
| Defining Change(s) |
| ||
| Allele Name | HLA-DQA1*02:01 | ||
| Genotype(s) | Not Available | ||
| Type(s) | ADR Directly Studied | ||
| Groups | Not Available | ||
| Description | The presence of this polymorphism in TNXB may indicate an increased risk of drug-induced ALT-elevations leading to hepatotoxicity when treated with lapatinib. | ||
| References |
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