Pharmacogenomic Effect/ADR for Tamoxifen (DBSNPE005861)

Identifier
DBSNPE005861
Drug
DB00675 (Tamoxifen)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
Whole-gene deletionNot Available
Allele Name
CYP2D6*5
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor response to drug treatment, shorter time to relapse
References
  1. Gaedigk A, Blum M, Gaedigk R, Eichelbaum M, Meyer UA: Deletion of the entire cytochrome P450 CYP2D6 gene as a cause of impaired drug metabolism in poor metabolizers of the debrisoquine/sparteine polymorphism. Am J Hum Genet. 1991 May;48(5):943-50. [PubMed:1673290]
  2. Steen VM, Molven A, Aarskog NK, Gulbrandsen AK: Homologous unequal cross-over involving a 2.8 kb direct repeat as a mechanism for the generation of allelic variants of human cytochrome P450 CYP2D6 gene. Hum Mol Genet. 1995 Dec;4(12):2251-7. [PubMed:8634695]
  3. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]