DrugDB00675 (Tamoxifen)
Interacting Gene/EnzymeCytochrome P450 2D6
Gene NameCYP2D6
UniProt IDP10635
Defining Change(s)
Allele NameCYP2D6*12
Genotype(s)Not Available
Type(s)Effect Inferred
GroupsNon-functional CYP2D6
DescriptionPoor response to drug treatment, shorter time to relapse
  1. Marez D, Legrand M, Sabbagh N, Lo-Guidice JM, Boone P, Broly F: An additional allelic variant of the CYP2D6 gene causing impaired metabolism of sparteine. Hum Genet. 1996 May;97(5):668-70. [PubMed:8655150 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]