IdentifierDBSNPE005883
DrugDB00675 (Tamoxifen)
Interacting Gene/EnzymeCytochrome P450 2D6
Gene NameCYP2D6
UniProt IDP10635
Defining Change(s)
  • 4044C>T
Allele NameCYP2D6*62
Genotype(s)Not Available
Type(s)Effect Inferred
GroupsNon-functional CYP2D6
DescriptionPoor response to drug treatment, shorter time to relapse
References
  1. Klein K, Tatzel S, Raimundo S, Saussele T, Hustert E, Pleiss J, Eichelbaum M, Zanger UM: A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6. Drug Metab Dispos. 2007 Aug;35(8):1247-50. Epub 2007 Apr 25. [PubMed:17460029 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]