Pharmacogenomic Effect/ADR for Tamoxifen (DBSNPE005885)

Identifier
DBSNPE005885
Drug
DB00675 (Tamoxifen)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
Similar but not identical switch region compared to CYP2D6*68A. Found in tandem arrangement with CYP2D6*4.Not Available
Allele Name
CYP2D6*68B
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor response to drug treatment, shorter time to relapse
References
  1. Gaedigk A, Twist GP, Leeder JS: CYP2D6, SULT1A1 and UGT2B17 copy number variation: quantitative detection by multiplex PCR. Pharmacogenomics. 2012 Jan;13(1):91-111. doi: 10.2217/pgs.11.135. Epub 2011 Nov 23. [PubMed:22111604]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]