DrugDB00675 (Tamoxifen)
Interacting Gene/EnzymeCytochrome P450 2D6
Gene NameCYP2D6
UniProt IDP10635
Defining Change(s)
-1426C>TNot Available
-1235A>GNot Available
-1109C>TNot Available
-1000G>ANot Available
100C>TNot Available
310G>TNot Available
843T>GNot Available
1039C>TNot Available
1661G>CNot Available
2097A>GNot Available
2828delCNot Available
3384A>CNot Available
3582A>GNot Available
4180G>CNot Available
4401C>TNot Available
Allele NameCYP2D6*100
Genotype(s)Not Available
Type(s)Effect Inferred
GroupsNon-functional CYP2D6
DescriptionPoor response to drug treatment, shorter time to relapse
  1. Montane Jaime LK, Lalla A, Steimer W, Gaedigk A: Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants. Pharmacogenomics. 2013 Feb;14(3):261-76. doi: 10.2217/pgs.12.207. [PubMed:23394389 ]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]