Pharmacogenomic Effect/ADR for Tamoxifen (DBSNPE005889)

Identifier
DBSNPE005889
Drug
DB00675 (Tamoxifen)
Interacting Gene/Enzyme
Cytochrome P450 2D6
Gene Name
CYP2D6
UniProt ID
P10635
Defining Change(s)
-1426C>TNot Available
-1235A>GNot Available
-1000G>ANot Available
100C>TNot Available
310G>TNot Available
843T>GNot Available
1039C>TNot Available
1661G>CNot Available
2097A>GNot Available
2927_2945delGATCCTACATCCGGATGTGNot Available
3384A>CNot Available
3582A>GNot Available
4180G>CNot Available
4401C>TNot Available
Allele Name
CYP2D6*101
Genotype(s)
Not Available
Type(s)
Effect Inferred
Groups
Non-functional CYP2D6
Description
Poor response to drug treatment, shorter time to relapse
References
  1. Montane Jaime LK, Lalla A, Steimer W, Gaedigk A: Characterization of the CYP2D6 gene locus and metabolic activity in Indo- and Afro-Trinidadians: discovery of novel allelic variants. Pharmacogenomics. 2013 Feb;14(3):261-76. doi: 10.2217/pgs.12.207. [PubMed:23394389]
  2. The Human Cytochrome P450 (CYP) Allele Nomenclature Database [Link]