IdentifierDBSNPE006085
DrugDB01418 (Acenocoumarol)
Interacting Gene/EnzymeCytochrome P450 2C9
Gene NameCYP2C9
UniProt IDP11712
Defining Change(s)
T Allelers1799853
Allele NameCYP2C9*2
Genotype(s)(T;T) / (C;T)
Type(s)Effect Directly Studied
GroupsNon-functional CYP2C9; Decreased CYP2C9
DescriptionThe presence of this polymorphism in CYP2C9 is associated with reduction in acenocoumarol metabolism.
References
  1. Saraeva RB, Paskaleva ID, Doncheva E, Eap CB, Ganev VS: Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirements. J Clin Pharm Ther. 2007 Dec;32(6):641-9. [PubMed:18021343 ]