Pharmacogenomic Effect/ADR for Acenocoumarol (DBSNPE006086)

Identifier
DBSNPE006086
Drug
DB01418 (Acenocoumarol)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
C Allelers1057910
Allele Name
CYP2C9*3
Genotype(s)
(C;C) / (A;C)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C9; Decreased CYP2C9
Description
The presence of this polymorphism in CYP2C9 is associated with reduction in acenocoumarol metabolism.
References
  1. Saraeva RB, Paskaleva ID, Doncheva E, Eap CB, Ganev VS: Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirements. J Clin Pharm Ther. 2007 Dec;32(6):641-9. [PubMed:18021343]