Pharmacogenomic Effect/ADR for Acenocoumarol (DBSNPE006087)

Identifier
DBSNPE006087
Drug
DB01418 (Acenocoumarol)
Interacting Gene/Enzyme
Vitamin K epoxide reductase complex subunit 1
Gene Name
VKORC1
UniProt ID
Q9BQB6
Defining Change(s)
G > Ars9934438
Allele Name
Not Available
Genotype(s)
(A;A) / (A;G)
Type(s)
ADR Directly Studied
Groups
Not Available
Description
The presence of this single nucleotide polymorphism in VKORC1 is associated with reduction in acenocoumarol metabolism and increased risk of drug-related hemorrhage.
References
  1. Schalekamp T, Brasse BP, Roijers JF, Chahid Y, van Geest-Daalderop JH, de Vries-Goldschmeding H, van Wijk EM, Egberts AC, de Boer A: VKORC1 and CYP2C9 genotypes and acenocoumarol anticoagulation status: interaction between both genotypes affects overanticoagulation. Clin Pharmacol Ther. 2006 Jul;80(1):13-22. [PubMed:16815313]