Pharmacogenomic Effect/ADR for Acenocoumarol (DBSNPE006088)

Identifier
DBSNPE006088
Drug
DB01418 (Acenocoumarol)
Interacting Gene/Enzyme
Cytochrome P450 2C9
Gene Name
CYP2C9
UniProt ID
P11712
Defining Change(s)
T Allelers1799853
Allele Name
CYP2C9*2
Genotype(s)
(T;T) / (C;T)
Type(s)
Effect Directly Studied
Groups
Non-functional CYP2C9; Decreased CYP2C9
Description
Patients with this polymorphism in CYP2C9 may be at a higher risk of developing drug-related hemorrhage or thrombosis when treated with acenocoumarol.
References
  1. Misasi S, Martini G, Paoletti O, Calza S, Scovoli G, Marengoni A, Testa S, Caimi L, Marchina E: VKORC1 and CYP2C9 polymorphisms related to adverse events in case-control cohort of anticoagulated patients. Medicine (Baltimore). 2016 Dec;95(52):e5451. doi: 10.1097/MD.0000000000005451. [PubMed:28033245]