IdentifierDBSNPE006089
DrugDB01418 (Acenocoumarol)
Interacting Gene/EnzymeCytochrome P450 2C9
Gene NameCYP2C9
UniProt IDP11712
Defining Change(s)
C Allelers1057910
Allele NameCYP2C9*3
Genotype(s)(C;C) / (A;C)
Type(s)Effect Directly Studied
GroupsNon-functional CYP2C9; Decreased CYP2C9
DescriptionPatients with this polymorphism in CYP2C9 may be at a higher risk of developing drug-related hemorrhage or thrombosis when treated with acenocoumarol.
References
  1. Misasi S, Martini G, Paoletti O, Calza S, Scovoli G, Marengoni A, Testa S, Caimi L, Marchina E: VKORC1 and CYP2C9 polymorphisms related to adverse events in case-control cohort of anticoagulated patients. Medicine (Baltimore). 2016 Dec;95(52):e5451. doi: 10.1097/MD.0000000000005451. [PubMed:28033245 ]